Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

Understanding global communications among cells requires accurate representation of cell-
cell signaling links and effective systems-level analyses of those links. We construct a …

INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …

The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to
antigens and commensals, and a tissue susceptible to one of the most prevalent human …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …