Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

The past few decades have seen a marked change in the composition of commonly smoked
cannabis. These changes primarily involve an increase of the psychoactive compound∆ 9 …

Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …

Background Cannabis is one of the most widely used drugs worldwide. Cannabis use
disorder is characterised by recurrent use of cannabis that causes significant clinical and …

In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …

The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

The corollaries of the obesity epidemic that plagues developed societies are malnutrition
and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty …

Cannabis is one of the most widely used illicit substances and there is growing interest in
the association between cannabis use and psychosis. Delta-9-Tetrahydrocannabinol (Δ-9 …

Two are the issues on cannabis addiction that provoke more controversy from a research
perspective. The first one is related to the development of tolerance phenomena and, in …

Cannabis is one of the most used drugs of abuse. It affects the brain reward system in
animals, and has proven rewarding and addictive potential in humans. We used functional …