[HTML][HTML] Toll-like receptor 4 upregulation by angiotensin II contributes to hypertension and vascular dysfunction through reactive oxygen species production

PR De Batista, R Palacios, A Martin, R Hernanz… - PloS one, 2014 - journals.plos.org
Hypertension is considered as a low-grade inflammatory disease, with adaptive immunity
being an important mediator of this pathology. TLR4 may have a role in the development of …

A tale of two proteins: PACT and PKR and their roles in inflammation

E Chukwurah, KT Farabaugh, BJ Guan… - The FEBS …, 2021 - Wiley Online Library
Inflammation is a pathological hallmark associated with bacterial and viral infections,
autoimmune diseases, genetic disorders, obesity and diabetes, as well as environmental …

[HTML][HTML] Innate immune cells and hypertension: neutrophils and neutrophil extracellular traps (NETs)

CG McCarthy, P Saha, RM Golonka… - Comprehensive …, 2021 - ncbi.nlm.nih.gov
Uncontrolled immune system activation amplifies end-organ injury in hypertension.
Nonetheless, the exact mechanisms initiating this exacerbated inflammatory response …

Myocyte signalling in leucocyte recruitment to the heart

A Ghigo, I Franco, F Morello, E Hirsch - Cardiovascular research, 2014 - academic.oup.com
Myocardial damage, by different noxious causes, triggers an inflammatory reaction driving
post-injury repair mechanisms and chronic remodelling processes that are largely …

Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress

JC Bikomeye, JD Terwoord… - American Journal of …, 2022 - journals.physiology.org
Many anticancer therapies (CTx) have cardiotoxic side effects that limit their therapeutic
potential and cause long-term cardiovascular complications in cancer survivors. This has …

Gut microbiota disorder, gut epithelial and blood–brain barrier dysfunctions in etiopathogenesis of dementia: molecular mechanisms and signaling pathways

MO Welcome - NeuroMolecular Medicine, 2019 - Springer
Emerging evidences indicate a critical role of the gut microbiota in etiopathogenesis of
dementia, a debilitating multifactorial disorder characterized by progressive deterioration of …

Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes

Y Wang, E Song, B Bai, PM Vanhoutte - Pharmacology & therapeutics, 2016 - Elsevier
Toll-like receptors (TLR) are a subfamily of pattern recognition receptors (PRR) implicated in
a variety of vascular abnormalities. However, the pathophysiological role and the interplay …

The role of complement in arterial hypertension and hypertensive end organ damage

UO Wenzel, C Kemper, M Bode - British journal of …, 2021 - Wiley Online Library
Increasing evidence indicates that hypertension and hypertensive end organ damage are
not only mediated by haemodynamic injury but that inflammation also plays an important …

[HTML][HTML] The role of hyperuricemia on vascular endothelium dysfunction

H Zhen, F Gui - Biomedical reports, 2017 - spandidos-publications.com
Hyperuricemia appears to be associated with an increased risk for cardiovascular disease
and associated mortality. Population epidemiological data support a causal link between …

[HTML][HTML] Gambaran faktor risiko dan tingkat risiko stroke iskemik berdasarkan stroke risk scorecard di RSUD Klungkung

NMTS Kesuma, DK Dharmawan… - Intisari Sains …, 2019 - mailin.isainsmedis.id
Abstract Latar Belakang: Indonesia memiliki angka beban stroke terbanyak kedua setelah
Mongolia yaitu sebanyak 3.382, 2/100.000 orang berdasarkan DALYs (disability-adjusted …