We recently discovered that endothelial Nogo-B, a membrane protein of the ER, regulates
vascular function by inhibiting the rate-limiting enzyme, serine palmitoyltransferase (SPT), in …

C-reactive protein (CRP) is an acute-phase protein produced in high quantities by the liver
in response to infection and during chronic inflammatory disorders. Although CRP is known …

Hyperglycemia-induced reactive oxygen species (ROS) production plays a major role in the
pathogenesis of diabetic vascular dysfunction. However, the underlying mechanisms remain …

Circulating cell-free mitochondrial DNA (ccf-mtDNA) acts as a damage-associated molecular
pattern molecule and may be cargo within extracellular vesicles (EVs). ccf-mtDNA and select …

Sjögren's syndrome (SS) is a systemic autoimmune disorder with an estimated global
prevalence of 0.3 to 1/1000 persons. This disease has a female predilection and mainly …

Acute kidney injury (AKI) involves nephron injury leading to irreversible nephron loss, ie,
chronic kidney disease (CKD). Both AKI and CKD are associated with distinct histological …

Autonomic dysfunction and abnormal immunity lead to systemic inflammatory responses,
which result in cardiovascular damage in hypertension. The aim of this report was to …

In response to heat stress, interleukin-6 (IL-6) expression is upregulated in broiler chickens.
The main aim of the present study was to evaluate the cumulative effects of thermal …

Context• COVID-19 has spread rapidly around the world and reached pandemic
proportions. With no definitive treatment to date, prevention is critical, and strengthening the …

Hypertension is the major risk factor for morbidity and mortality from myocardial infarction,
stroke, heart failure, and chronic kidney disease. Despite its importance, the pathogenesis of …