The detection of infectious pathogens is essential for the induction of antimicrobial immune
responses. The innate immune system detects a wide array of microbes using a limited set …

Arterial hypertension represents a serious public health problem, being a major cause of
morbidity and mortality worldwide. The availability of many antihypertensive therapeutic …

Hypertension is the most common chronic cardiovascular disease and is associated with
several pathological states, being an important cause of morbidity and mortality around the …

Hypertension affects nearly 1.2 billion people worldwide and challenges health systems with
its myriad complications. While the molecular mechanisms underlying this disease are yet to …

Stiffening of large arteries is increasingly used as an independent predictor of risk and
therapeutic outcome for small artery dysfunction in many diseases including pulmonary …

Heart failure (HF) is a leading cause of morbidity and mortality in the western world.
Although optimal medical care and treatment is widely available, the prognosis of patients …

In this study, the aim was to investigate effects of chronic heat stress (CHS) on the mRNA
levels of proinflammatory cytokines (interleukin [IL]-6, IL-8, IL-1β, and tumor necrosis factor …

Abstract Myeloid differentiation protein 1 (MD1) has been implicated in numerous
pathophysiological processes, including immune regulation, obesity, insulin resistance, and …

Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the
mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that is …

Abstract Toll-like receptor 4 (TLR4) is an important mediator of hypertension and AngII
induced cardiac inflammation and remodelling. In this study, the potential of nerolidol to …