Traditionally, Toll-like receptor 9 (TLR9) signals through an MyD88-dependent cascade that
results in proinflammatory gene transcription. Recently, it was reported that TLR9 also …

Background: We previously reported increased plasma XO (xanthine oxidase) activity in
patients with resistant hypertension. Increased XO can cause mitochondrial DNA damage …

This study aimed to investigate whether the proinflammatory and pressor effects of
endogenous angiotensin II (AngII) are mediated by binding to the AngII type 1 receptor …

Abstract Due to Butylparaben (BuP) widespread application in cosmetics, food,
pharmaceuticals, and its presence as an environmental residue, human and animal …

Intracranial aneurysm (IA) is a cerebrovascular disease with a high mortality rate. The
pathogenesis of IA remains unclear and the treatment limited. The purpose of the present …

Humans are exposed to harmful pathogens and a wide range of noxious substances every
day. The immune system reacts to, and destroys, these pathogens and harmful substances …

We have previously shown that liposomes composed of egg-derived phosphatidylglycerol
(PG), with a mixed fatty acid composition (comprising mainly palmitate and oleate), inhibit …

Immunotherapy has revolutionized cancer treatment, with sustained responses to immune
checkpoint inhibitors reported in a number of malignancies. Such therapeutics are now …

Many studies have shown that fluorosis due to long-term fluoride intake has damaging
effects on the heart. However, the mechanisms underlying cardiac fluorosis have not been …

Background and aims Cell-free DNA (cfDNA) is elevated in several disease states.
Metabolic syndrome is a constellation of factors associated with poor cardiometabolic …