Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate

FC Gomes, LGA Chuffa, WR Scarano, PFF Pinheiro… - …, 2016 - Wiley Online Library
Age is a key factor in the development of prostatic lesions. An increase in reactive oxygen
species levels occurs during aging. Furthermore, the indiscriminate use of anabolic …

[HTML][HTML] The toll of the gridiron: damage-associated molecular patterns and hypertension in American football

CG McCarthy, RC Webb - The FASEB Journal, 2016 - ncbi.nlm.nih.gov
American football has unequivocally been linked to elevations in blood pressure and
hypertension, especially in linemen. However, the mechanisms of this increase cannot be …

Autoimmune therapeutic chloroquine lowers blood pressure and improves endothelial function in spontaneously hypertensive rats

CG McCarthy, CF Wenceslau, S Goulopoulou… - Pharmacological …, 2016 - Elsevier
It has been suggested that hypertension results from a loss of immunological tolerance and
the resulting autoimmunity may be an important underlying factor of its pathogenesis. This …

Toll-like receptor 4 stimulates gene expression via Smad2 linker region phosphorylation in vascular smooth muscle cells

R Afroz, Y Zhou, PJ Little, S Xu… - ACS Pharmacology & …, 2020 - ACS Publications
Atherosclerosis begins in the vessel wall with the retention of low density lipoproteins to
modified proteoglycans with hyperelongated glycosaminoglycan (GAG) chains. Bacterial …

T-cell involvement in sex differences in blood pressure control

GR Crislip, JC Sullivan - Clinical Science, 2016 - portlandpress.com
Hypertension affects one-third of adults in the Western world and is the most common
independent risk factor for cardiovascular disease, and the leading cause of premature …

Impact of TLR7 and TLR9 polymorphisms on susceptibility to placental infections and pregnancy complications

K Sanchez-Luquez, IC Schadock, CV Goncalves… - Journal of Reproductive …, 2021 - Elsevier
This study evaluated the impact of the TLR7 Gln11Leu (rs179008) and TLR9− 1237 T/C
(rs5743836) single nucleotide polymorphisms (SNPs) on susceptibility to placental …

Out of the frying pan and into the fire: damage-associated molecular patterns and cardiovascular toxicity following cancer therapy

NS Klee, CG McCarthy… - Therapeutic …, 2017 - journals.sagepub.com
Cardio-oncology is a new and rapidly expanding field that merges cancer and
cardiovascular disease. Cardiovascular disease is an omnipresent side effect of cancer …

Genetic disruption of Npr1 depletes regulatory T cells and provokes high levels of proinflammatory cytokines and fibrosis in the kidneys of female mutant mice

VR Gogulamudi, I Mani… - American Journal of …, 2019 - journals.physiology.org
The present study was designed to determine the effects of gene knockout of guanylyl
cyclase/natriuretic peptide receptor-A (GC-A/NPRA) on immunogenic responses affecting …

[HTML][HTML] Current perspectives and mechanisms of relationship between intestinal microbiota dysfunction and dementia: a review

MO Welcome - Dementia and Geriatric Cognitive Disorders Extra, 2019 - karger.com
Background: Accumulating data suggest a crucial role of the intestinal microbiota in the
development and progression of neurodegenerative diseases. More recently, emerging …

Kruppel-like factor 10 protects against acute viral myocarditis by negatively regulating cardiac MCP-1 expression

J Yang, H Zhang, X Wang, J Guo, L Wei… - Cellular & Molecular …, 2021 - nature.com
Viral myocarditis (VMC) is a cardiac disease associated with myocardial inflammation and
injury induced by virus infection. Cardiomyocytes have recently been regarded as key …