Fluorinated molecules have a wide range of applications and are used as medicines,
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …

This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …

Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

New methods for preparation of tailor-made fluorine-containing compounds are in extremely
high demand in nearly every sector of chemical industry. The asymmetric construction of …

Selective functionalization of inactive C (sp3)–F bonds to prepare medicinally interesting
aryldifluoromethylated compounds remains challenging. One promising route is the …

Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

This Review summarizes advances in fluorination by C (sp2)− H and C (sp3)− H activation.
Transition‐metal‐catalyzed approaches championed by palladium have allowed the …

The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

The elaboration of step-economy and catalytic approaches for accessing diverse fluorinated
heterocyclics is highly desirable. Described herein is a radical-polar crossover enabled …