Origin and proliferation of multiple-drug resistance in bacterial pathogens
Many studies report the high prevalence of multiply drug-resistant (MDR) strains. Because
MDR infections are often significantly harder and more expensive to treat, they represent a …
MDR infections are often significantly harder and more expensive to treat, they represent a …
Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis
Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …
economically active young adults, and has high mortality irrespective of HIV status. In some …
[HTML][HTML] The potential impact of the COVID-19 pandemic on the tuberculosis epidemic a modelling analysis
Background Routine services for tuberculosis (TB) are being disrupted by stringent
lockdowns against the novel SARS-CoV-2 virus. We sought to estimate the potential long …
lockdowns against the novel SARS-CoV-2 virus. We sought to estimate the potential long …
Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled …
Summary Background The Xpert MTB/RIF test for tuberculosis is being rolled out in many
countries, but evidence is lacking regarding its implementation outside laboratories, ability to …
countries, but evidence is lacking regarding its implementation outside laboratories, ability to …
[HTML][HTML] Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert …
GJ Churchyard, WS Stevens, LD Mametja… - The Lancet Global …, 2015 - thelancet.com
Summary Background In South Africa, sputum smear microscopy has been replaced with
Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster …
Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster …
[HTML][HTML] Feasibility of achieving the 2025 WHO global tuberculosis targets in South Africa, China, and India: a combined analysis of 11 mathematical models
Summary Background The post-2015 End TB Strategy proposes targets of 50% reduction in
tuberculosis incidence and 75% reduction in mortality from tuberculosis by 2025. We aimed …
tuberculosis incidence and 75% reduction in mortality from tuberculosis by 2025. We aimed …
Estimating the future burden of multidrug-resistant and extensively drug-resistant tuberculosis in India, the Philippines, Russia, and South Africa: a mathematical …
A Sharma, A Hill, E Kurbatova… - The Lancet Infectious …, 2017 - thelancet.com
Background Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis
are emerging worldwide. The Green Light Committee initiative supported programmatic …
are emerging worldwide. The Green Light Committee initiative supported programmatic …
Global tuberculosis targets and milestones set for 2016–2035: definition and rationale
BACKGROUND: Global tuberculosis (TB) targets were set as part of the World Health
Organization's End TB Strategy (2016–2035) and the Sustainable Development Goals …
Organization's End TB Strategy (2016–2035) and the Sustainable Development Goals …
[HTML][HTML] Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 …
JW Eaton, NA Menzies, J Stover… - The Lancet Global …, 2014 - thelancet.com
Background New WHO guidelines recommend initiation of antiretroviral therapy for HIV-
positive adults with CD4 counts of 500 cells per μL or less, a higher threshold than was …
positive adults with CD4 counts of 500 cells per μL or less, a higher threshold than was …
The point-of-care laboratory in clinical microbiology
M Drancourt, A Michel-Lepage, S Boyer… - Clinical microbiology …, 2016 - Am Soc Microbiol
SUMMARY Point-of-care (POC) laboratories that deliver rapid diagnoses of infectious
diseases were invented to balance the centralization of core laboratories. POC laboratories …
diseases were invented to balance the centralization of core laboratories. POC laboratories …