Impact of aging brain circuits on cognition

RD Samson, CA Barnes - European journal of neuroscience, 2013 - Wiley Online Library
Brain networks that engage the hippocampus and prefrontal cortex are central for enabling
effective interactions with our environment. Some of the cognitive processes that these …

Lifespan age differences in working memory: A two-component framework

MC Sander, U Lindenberger… - … & Biobehavioral Reviews, 2012 - Elsevier
We suggest that working memory (WM) performance can be conceptualized as the interplay
of low-level feature binding processes and top-down control, relating to posterior and frontal …

Increased prefrontal activity with aging reflects nonspecific neural responses rather than compensation

AM Morcom, RNA Henson - Journal of Neuroscience, 2018 - Soc Neuroscience
Elevated prefrontal cortex activity is often observed in healthy older adults despite declines
in their memory and other cognitive functions. According to one view, this activity reflects a …

Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding

A Maass, H Schütze, O Speck, A Yonelinas… - Nature …, 2014 - nature.com
The ability to form long-term memories for novel events depends on information processing
within the hippocampus (HC) and entorhinal cortex (EC). The HC–EC circuitry shows a …

Neural reorganization and compensation in aging

AM Morcom, W Johnson - Journal of cognitive neuroscience, 2015 - direct.mit.edu
According to prominent theories of aging, the brain may reorganize to compensate for neural
deterioration and prevent or offset cognitive decline. A frequent and striking finding in …

Action controls dopaminergic enhancement of reward representations

M Guitart-Masip, R Chowdhury… - Proceedings of the …, 2012 - National Acad Sciences
Dopamine is widely observed to signal anticipation of future rewards and thus thought to be
a key contributor to affectively charged decision making. However, the experiments …

CA3 size predicts the precision of memory recall

MJ Chadwick, HM Bonnici… - Proceedings of the …, 2014 - National Acad Sciences
There is enduring interest in why some of us have clearer memories than others, given the
substantial individual variation that exists in retrieval ability and the precision with which we …

Reduced fidelity of neural representation underlies episodic memory decline in normal aging

L Zheng, Z Gao, X Xiao, Z Ye, C Chen, G Xue - Cerebral Cortex, 2018 - academic.oup.com
Emerging studies have emphasized the importance of the fidelity of cortical representation in
forming enduring episodic memory. No study, however, has examined whether there are …

Action-specific value signals in reward-related regions of the human brain

THB FitzGerald, KJ Friston, RJ Dolan - Journal of Neuroscience, 2012 - Soc Neuroscience
Estimating the value of potential actions is crucial for learning and adaptive behavior. We
know little about how the human brain represents action-specific value outside of motor …

Bayesian models for functional magnetic resonance imaging data analysis

L Zhang, M Guindani… - Wiley Interdisciplinary …, 2015 - Wiley Online Library
Functional magnetic resonance imaging (fMRI), a noninvasive neuroimaging method that
provides an indirect measure of neuronal activity by detecting blood flow changes, has …