Carbapenem resistance in gram-negative bacteria has caused a global epidemic that
continues to grow. Although carbapenemase-producing Enterobacteriaceae have received …

Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged,
disseminated globally and become a leading cause of bacterial infections in both health …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is
increasingly dominated by the mobilization of continuously expressed single genes that …

Not only is Asia the most populous region in the world, but inappropriate therapy, including
seif-medication with over-the-counter antimicrobial agents, is a common response to …

Background: Since the initial appearance in the 1980s, Enterobacteriaceae producing
extended-spectrum β-lactamase (ESBL) have increased in prevalence and emerged as a …

Metallo-β-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important
nosocomial pathogen that shows resistance to all β-lactam antibiotics except monobactams …

ABSTRACT Metallo-β-lactamases (MBLs) hydrolyze all classes of β-lactams except
monobactams and are not inhibited by classic serine β-lactamase inhibitors. Gram-negative …

Carbapenem-resistant Enterobacteriaceae infections have spread globally, leaving
polymyxins, including colistin, as 'last-resort treatments'. Emerging colistin resistance raises …

The in vitro activities of ceftazidime-avibactam and comparators against 9,149 isolates of
Enterobacteriaceae and 2,038 isolates of Pseudomonas aeruginosa collected by 42 …