[HTML][HTML] Metals to combat antimicrobial resistance

A Frei, AD Verderosa, AG Elliott, J Zuegg… - Nature Reviews …, 2023 - nature.com
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

[HTML][HTML] Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review

AC Munteanu, V Uivarosi - Pharmaceutics, 2021 - mdpi.com
The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Carbon‐monoxide‐releasing molecules for the delivery of therapeutic CO in vivo

S García‐Gallego… - Angewandte Chemie …, 2014 - Wiley Online Library
The development of carbon‐monoxide‐releasing molecules (CORMs) as pharmaceutical
agents represents an attractive and safer alternative to administration of gaseous CO. Most …

Red light‐triggered intracellular carbon monoxide release enables selective eradication of MRSA infection

J Cheng, G Gan, Z Shen, L Gao, G Zhang… - Angewandte …, 2021 - Wiley Online Library
Carbon monoxide (CO) is an important gaseous signaling molecule. The use of CO‐
releasing molecules such as metal carbonyls enables the elucidation of the pleiotropic …

[HTML][HTML] A thiol-reactive Ru (II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

HM Southam, TW Smith, RL Lyon, C Liao, CR Trevitt… - Redox biology, 2018 - Elsevier
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds,
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …

The Triple Crown: NO, CO, and H2S in cancer cell biology

PP Oza, K Kashfi - Pharmacology & Therapeutics, 2023 - Elsevier
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are three
endogenously produced gases with important functions in the vasculature, immune defense …

[HTML][HTML] 'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects

HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …

The microbiology of ruthenium complexes

HM Southam, JA Butler, JA Chapman… - Advances in microbial …, 2017 - Elsevier
Ruthenium is seldom mentioned in microbiology texts, due to the fact that this metal has no
known, essential roles in biological systems, nor is it generally considered toxic. Since the …

[HTML][HTML] CO-releasing metal carbonyl compounds as antimicrobial agents in the post-antibiotic era

LK Wareham, RK Poole, M Tinajero-Trejo - Journal of Biological Chemistry, 2015 - ASBMB
The possibility of a" post-antibiotic era" in the 21st century, in which common infections may
kill, has prompted research into radically new antimicrobials. CO-releasing molecules …

Introducing [Mn (CO) 3 (tpa-κ 3 N)]+ as a novel photoactivatable CO-releasing molecule with well-defined iCORM intermediates–synthesis, spectroscopy, and …

C Nagel, S McLean, RK Poole, H Braunschweig… - Dalton …, 2014 - pubs.rsc.org
[Mn (CO) 3 (tpa-κ3N)] Br was prepared as a novel photoactivatable CO-releasing molecule
(PhotoCORM) from [MnBr (CO) 5] and tris (2-pyridylmethyl) amine (tpa) for the delivery of …