Managing sars-cov2 infections through resolution of inflammation by eicosanoids: A review
A Mohammed, AM Kalle… - Journal of Inflammation …, 2022 - Taylor & Francis
Abstract Severe Corona Virus Disease is characterized by angiocentric inflammation of
lungs and cytokine storm leading to potentially fatal multiple organ failure. Several studies …
lungs and cytokine storm leading to potentially fatal multiple organ failure. Several studies …
Cardiomyocyte-specific CYP2J2 and its therapeutic implications
R Valencia, W Bassiouni, AM Darwesh… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction Cytochrome P450s (CYPs) are a superfamily of monooxygenases
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …
[HTML][HTML] Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts
AV Karkhanis, G Venkatesan, R Kambayashi… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …
[HTML][HTML] Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes
JWH Leow, Y Gu, ECY Chan - European Journal of Pharmaceutical …, 2023 - Elsevier
Abstract Cardiac cytochrome P450 2J2 (CYP2J2) metabolizes endogenous polyunsaturated
fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosatrienoic acid (EET) …
fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosatrienoic acid (EET) …
Inhibition of cytochrome P450 2J2-mediated metabolism of rivaroxaban and arachidonic acid by ibrutinib and osimertinib
Covalent tyrosine kinase inhibitors (TKIs) ibrutinib and osimertinib are associated with
cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly …
cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly …
Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology
Atypical kinetics are observed in metabolic reactions catalyzed by cytochrome P450
enzymes (P450). Yet, this phenomenon is regarded as experimental artifacts in some …
enzymes (P450). Yet, this phenomenon is regarded as experimental artifacts in some …
CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control
JWH Leow, ECY Chan - Pharmacology & Therapeutics, 2024 - Elsevier
Abstract Cytochrome P450 2 J2 (CYP2J2) is primarily expressed extrahepatically and is the
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review
AM Wiley, J Yang, R Madhani, A Nath… - Drug Metabolism …, 2024 - Taylor & Francis
Drug withdrawal post-marketing due to cardiotoxicity is a major concern for drug developers,
regulatory agencies, and patients. One common mechanism of cardiotoxicity is through …
regulatory agencies, and patients. One common mechanism of cardiotoxicity is through …
Physiologically Based Pharmacokinetic Modeling of Vitamin D3 and Metabolites in Vitamin D–Insufficient Patients
CW Sawyer, SM Tuey, RE West, TD Nolin… - Drug Metabolism and …, 2022 - ASPET
A physiologically based pharmacokinetic (PBPK) model of vitamin D3 and metabolites [25
(OH) D3, 1, 25 (OH) 2D3, and 24, 25 (OH) 2D3] is presented. In this study, patients with 25 …
(OH) D3, 1, 25 (OH) 2D3, and 24, 25 (OH) 2D3] is presented. In this study, patients with 25 …
A Newly Synthesized β-amino-α, β-unsaturated Ketone Derivative of β-himachalene: Structural, NBO, NLO, and Molecular Docking Studies
MA El Had - 2022 - digibug.ugr.es
In the current study, a new β-amino-α, β-unsaturated ketone-based himachalene ((1S, 3R,
8R)-9-amino-2, 2-dichloro-3, 7, 7, 10-tetramethyltricyclo [6.4. 0.01, 3] dodec-9-en-11-one)(4) …
8R)-9-amino-2, 2-dichloro-3, 7, 7, 10-tetramethyltricyclo [6.4. 0.01, 3] dodec-9-en-11-one)(4) …