The molecular biology of sporadic acromegaly

D Marrero-Rodríguez, A Moscona-Nissan… - Best Practice & …, 2024 - Elsevier
GH-secreting tumors represent 15% to 20% of all pituitary neuroendocrine tiumors
(pitNETs), of which 95% occur in a sporadic context, without an identifiable inherited cause …

[HTML][HTML] The hidden hedgehog of the pituitary: hedgehog signaling in development, adulthood and disease of the hypothalamic-pituitary axis

Y Bian, H Hahn, A Uhmann - Frontiers in Endocrinology, 2023 - frontiersin.org
Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and
tumorigenesis. However, its engagement in the pituitary gland has been long …

[HTML][HTML] Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary …

S Lin, Y Dai, C Han, T Han, L Zhao, R Wu, J Liu… - Genome Medicine, 2024 - Springer
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are common gland
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …

[HTML][HTML] Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors

N Yan, W Xie, D Wang, Q Fang, J Guo, Y Chen, X Li… - Genome Medicine, 2024 - Springer
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are one of the most
common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary …

[HTML][HTML] Association between Intracellular Calcium Signaling and Tumor Recurrence in Human Non-Functioning Pituitary Adenomas

Y Santiago-Andres, A Aquiles… - International Journal of …, 2024 - mdpi.com
Clinically non-functioning pituitary adenomas (CNFPAs) are the second most frequent sellar
tumor among studies on community-dwelling adults. They are characterized by the absence …

Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors

D Marrero-Rodríguez, S Vela-Patiño… - Archives of Medical …, 2023 - Elsevier
Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and
nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea …

[HTML][HTML] Erythropoietin-producing hepatocellular receptor B6 is highly expressed in non-functioning pituitary neuroendocrine tumors and its expression correlates with …

H Rubinfeld, ZR Cohen, U Bendavid… - Molecular Biology …, 2024 - Springer
Background Erythropoietin-producing hepatocellular (EPH) receptors are the largest known
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …

Single‐cell sequencing, spatial transcriptome ad periodontitis: Rethink pathogenesis and classification

S Razzouk - Oral Diseases, 2023 - Wiley Online Library
Objective This narrative review illuminates on the application of single‐cell RNA sequencing
(scRNA‐seq) and spatial transcriptomics (ST) in periodontitis and highlights the probability …

[HTML][HTML] Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours

KA Øystese, NC Olarescu, C Lindskog… - Free …, 2024 - ncbi.nlm.nih.gov
Background: Cells with stem cell features have been described in pituitary neuroendocrine
tumours (PitNETs). Transcription factors SOX2 and SOX9 are stem cell-associated markers …

Clinical and Pathological Features of Pit1/SF1 Multilineage Pituitary Neuroendocrine Tumor

X Wang, H Tang, Z Bie, Y Wang, R Yuan, Z Zhang… - …, 2022 - journals.lww.com
METHODS: A retrospective study was conducted by reviewing 57 cases of Pit1/SF1-
adenoma between 2018 and 2022. We also included 88 cases of PitNET arising from Pit1 …