The molecular biology of sporadic acromegaly
D Marrero-Rodríguez, A Moscona-Nissan… - Best Practice & …, 2024 - Elsevier
GH-secreting tumors represent 15% to 20% of all pituitary neuroendocrine tiumors
(pitNETs), of which 95% occur in a sporadic context, without an identifiable inherited cause …
(pitNETs), of which 95% occur in a sporadic context, without an identifiable inherited cause …
[HTML][HTML] The hidden hedgehog of the pituitary: hedgehog signaling in development, adulthood and disease of the hypothalamic-pituitary axis
Y Bian, H Hahn, A Uhmann - Frontiers in Endocrinology, 2023 - frontiersin.org
Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and
tumorigenesis. However, its engagement in the pituitary gland has been long …
tumorigenesis. However, its engagement in the pituitary gland has been long …
[HTML][HTML] Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary …
S Lin, Y Dai, C Han, T Han, L Zhao, R Wu, J Liu… - Genome Medicine, 2024 - Springer
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are common gland
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …
[HTML][HTML] Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are one of the most
common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary …
common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary …
[HTML][HTML] Association between Intracellular Calcium Signaling and Tumor Recurrence in Human Non-Functioning Pituitary Adenomas
Y Santiago-Andres, A Aquiles… - International Journal of …, 2024 - mdpi.com
Clinically non-functioning pituitary adenomas (CNFPAs) are the second most frequent sellar
tumor among studies on community-dwelling adults. They are characterized by the absence …
tumor among studies on community-dwelling adults. They are characterized by the absence …
Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors
D Marrero-Rodríguez, S Vela-Patiño… - Archives of Medical …, 2023 - Elsevier
Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and
nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea …
nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea …
[HTML][HTML] Erythropoietin-producing hepatocellular receptor B6 is highly expressed in non-functioning pituitary neuroendocrine tumors and its expression correlates with …
H Rubinfeld, ZR Cohen, U Bendavid… - Molecular Biology …, 2024 - Springer
Background Erythropoietin-producing hepatocellular (EPH) receptors are the largest known
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …
Single‐cell sequencing, spatial transcriptome ad periodontitis: Rethink pathogenesis and classification
S Razzouk - Oral Diseases, 2023 - Wiley Online Library
Objective This narrative review illuminates on the application of single‐cell RNA sequencing
(scRNA‐seq) and spatial transcriptomics (ST) in periodontitis and highlights the probability …
(scRNA‐seq) and spatial transcriptomics (ST) in periodontitis and highlights the probability …
[HTML][HTML] Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours
KA Øystese, NC Olarescu, C Lindskog… - Free …, 2024 - ncbi.nlm.nih.gov
Background: Cells with stem cell features have been described in pituitary neuroendocrine
tumours (PitNETs). Transcription factors SOX2 and SOX9 are stem cell-associated markers …
tumours (PitNETs). Transcription factors SOX2 and SOX9 are stem cell-associated markers …
Clinical and Pathological Features of Pit1/SF1 Multilineage Pituitary Neuroendocrine Tumor
X Wang, H Tang, Z Bie, Y Wang, R Yuan, Z Zhang… - …, 2022 - journals.lww.com
METHODS: A retrospective study was conducted by reviewing 57 cases of Pit1/SF1-
adenoma between 2018 and 2022. We also included 88 cases of PitNET arising from Pit1 …
adenoma between 2018 and 2022. We also included 88 cases of PitNET arising from Pit1 …