Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate
during development, stem cell renewal and differentiation in postnatal tissues. Roles for …

The Notch pathway is increasingly attracting attention as a source of therapeutic targets for
cancer. Ligand-induced Notch signaling has been implicated in various aspects of cancer …

Aberrant activation of Notch signaling plays an oncogenic role in cancer development.
Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell …

The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem
and progenitor cells. These cell compartments are regulated to balance proliferation and …

Gastric cancer (GC) is the third leading cause of cancer mortality worldwide. Although
surgical resection is a potentially curative approach for localized cases of GC, most cases of …

Gastric cancer is a significant global health problem. It is the fifth most common cancer and
third leading cause of cancer-related death worldwide (Torre et al. in CA Cancer J Clin 65 …

Cancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless
advances in science has led to a decrease in the number of death cases caused by cancer …

The pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation
of intracellular signaling pathways represents a common pathogenic mechanism and may …

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for
esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of …

Abstract Background The Hippo pathway is widely considered to inhibit cell growth and play
an important role in regulating the size of organs. However, recent studies have shown that …