The concept of psoriasis as a systemic inflammation: implications for disease management

K Reich - Journal of the European Academy of Dermatology …, 2012 - Wiley Online Library
Psoriasis is a systemic, immune‐mediated disorder, characterized by inflammatory skin and
joint manifestations. A range of co‐morbidities is associated with psoriasis, including …

Psoriasis and cardiovascular comorbidities: focusing on severe vascular events, cardiovascular risk factors and implications for treatment

SCS Hu, CCE Lan - International journal of molecular sciences, 2017 - mdpi.com
Psoriasis is a common and chronic inflammatory disease of the skin. It may impair the
physical and psychosocial function of patients and lead to decreased quality of life …

Psoriasis and comorbid diseases: Implications for management

J Takeshita, S Grewal, SM Langan, NN Mehta… - Journal of the American …, 2017 - Elsevier
As summarized in the first article in this continuing medical education series, the currently
available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic …

Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

A Budu-Aggrey, B Brumpton, J Tyrrell, S Watkins… - PLoS …, 2019 - journals.plos.org
Background Psoriasis is a common inflammatory skin disease that has been reported to be
associated with obesity. We aimed to investigate a possible causal relationship between …

Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities

P Gisondi, F Bellinato, G Girolomoni… - Frontiers in …, 2020 - frontiersin.org
Psoriasis is a chronic, systemic immune-mediated disease characterized by development of
erythematous, indurated, scaly, pruritic plaques on the skin. Psoriasis is frequently …

Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis

CT Jordan, L Cao, EDO Roberson, S Duan… - The American Journal of …, 2012 - cell.com
Psoriasis is a common inflammatory disorder of the skin and other organs. We have
determined that mutations in CARD14, encoding a nuclear factor of kappa light chain …

Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment

E Guttman‐Yassky, JG Krueger… - Experimental …, 2018 - Wiley Online Library
Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases that negatively affect
patients' quality of life. Although distinctions exist between these diseases, both are …

[HTML][HTML] An integrated model of atopic dermatitis biomarkers highlights the systemic nature of the disease

B Ungar, S Garcet, J Gonzalez, N Dhingra… - Journal of Investigative …, 2017 - Elsevier
Current atopic dermatitis (AD) models link epidermal abnormalities in lesional skin to
cytokine activation. However, there is evolving evidence of systemic immune activation and …

Biomarkers of disease progression in people with psoriasis: a scoping review

R Ramessur, M Corbett, D Marshall… - British Journal of …, 2022 - academic.oup.com
Background Identification of those at risk of more severe psoriasis and/or associated
morbidities offers opportunity for early intervention, reduced disease burden and more cost …

Attributable risk estimate of severe psoriasis on major cardiovascular events

NN Mehta, YD Yu, R Pinnelas… - The American journal of …, 2011 - Elsevier
BACKGROUND: Recent studies suggest that psoriasis, particularly if severe, may be a risk
factor for major adverse cardiac events, such as myocardial infarction, stroke, and mortality …