More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy
M Flores-Leon, TF Outeiro - Acta neuropathologica, 2023 - Springer
The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
Lipid metabolism in glioblastoma: from de novo synthesis to storage
Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options,
novel therapies are desperately needed. Recent studies have shown that GBM acquires …
novel therapies are desperately needed. Recent studies have shown that GBM acquires …
Potential benefits of medium chain fatty acids in aging and neurodegenerative disease
E Dunn, B Zhang, VK Sahota… - Frontiers in Aging …, 2023 - frontiersin.org
Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …
The potential role of glucose metabolism, lipid metabolism, and amino acid metabolism in the treatment of Parkinson's disease
H Li, F Zeng, C Huang, Q Pu… - CNS neuroscience & …, 2024 - Wiley Online Library
Abstract Purpose of Review Parkinson's disease (PD) is a common neurodegenerative
disease, which can cause progressive deterioration of motor function causing muscle …
disease, which can cause progressive deterioration of motor function causing muscle …
Identification of key lipid metabolism-related genes in Alzheimer's disease
Y Zeng, S Cao, N Li, J Tang, G Lin - Lipids in Health and Disease, 2023 - Springer
Background Alzheimer's disease (AD) represents profound degenerative conditions of the
brain that cause significant deterioration in memory and cognitive function. Despite …
brain that cause significant deterioration in memory and cognitive function. Despite …
Blood proteome profiling reveals biomarkers and pathway alterations in Fragile X PM at risk for developing FXTAS
Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder
associated with the FMR1 premutation. Currently, it is not possible to determine when and if …
associated with the FMR1 premutation. Currently, it is not possible to determine when and if …
[HTML][HTML] The molecular mechanisms of the relationship between insulin resistance and Parkinson's disease pathogenesis
Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …
Fats, friends or foes: investigating the role of short-and medium-chain fatty acids in Alzheimer's disease
Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining
acceptance based on the pathophysiological commonalities between AD and major …
acceptance based on the pathophysiological commonalities between AD and major …
Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles
Lipids play a significant role in maintaining central nervous system (CNS) structure and
function, and the dysregulation of lipid metabolism is known to occur in many neurological …
function, and the dysregulation of lipid metabolism is known to occur in many neurological …
Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women
X Capo, AM Galmes-Panades… - International journal of …, 2023 - mdpi.com
This study aimed to assess the relationship between age-related changes in Neurofilament
Light Chain (NFL), a marker of neuronal function, and various factors including muscle …
Light Chain (NFL), a marker of neuronal function, and various factors including muscle …