More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy

M Flores-Leon, TF Outeiro - Acta neuropathologica, 2023 - Springer
The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …

Lipid metabolism in glioblastoma: from de novo synthesis to storage

Y Kou, F Geng, D Guo - Biomedicines, 2022 - mdpi.com
Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options,
novel therapies are desperately needed. Recent studies have shown that GBM acquires …

Potential benefits of medium chain fatty acids in aging and neurodegenerative disease

E Dunn, B Zhang, VK Sahota… - Frontiers in Aging …, 2023 - frontiersin.org
Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …

The potential role of glucose metabolism, lipid metabolism, and amino acid metabolism in the treatment of Parkinson's disease

H Li, F Zeng, C Huang, Q Pu… - CNS neuroscience & …, 2024 - Wiley Online Library
Abstract Purpose of Review Parkinson's disease (PD) is a common neurodegenerative
disease, which can cause progressive deterioration of motor function causing muscle …

Identification of key lipid metabolism-related genes in Alzheimer's disease

Y Zeng, S Cao, N Li, J Tang, G Lin - Lipids in Health and Disease, 2023 - Springer
Background Alzheimer's disease (AD) represents profound degenerative conditions of the
brain that cause significant deterioration in memory and cognitive function. Despite …

Blood proteome profiling reveals biomarkers and pathway alterations in Fragile X PM at risk for developing FXTAS

M Zafarullah, J Li, MR Salemi, BS Phinney… - International Journal of …, 2023 - mdpi.com
Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder
associated with the FMR1 premutation. Currently, it is not possible to determine when and if …

[HTML][HTML] The molecular mechanisms of the relationship between insulin resistance and Parkinson's disease pathogenesis

VA Ruiz-Pozo, R Tamayo-Trujillo, S Cadena-Ullauri… - Nutrients, 2023 - mdpi.com
Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …

Fats, friends or foes: investigating the role of short-and medium-chain fatty acids in Alzheimer's disease

AO Ameen, K Freude, BI Aldana - Biomedicines, 2022 - mdpi.com
Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining
acceptance based on the pathophysiological commonalities between AD and major …

Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles

H Su, CL Masters, AI Bush, KJ Barnham, GE Reid… - …, 2023 - Wiley Online Library
Lipids play a significant role in maintaining central nervous system (CNS) structure and
function, and the dysregulation of lipid metabolism is known to occur in many neurological …

Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women

X Capo, AM Galmes-Panades… - International journal of …, 2023 - mdpi.com
This study aimed to assess the relationship between age-related changes in Neurofilament
Light Chain (NFL), a marker of neuronal function, and various factors including muscle …