During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Germ cell formation and embryonic development require ATP synthesized by mitochondria.
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …

The female reproductive system is quite sensitive to regulation, and external environmental
stimuli may cause oxidative stress which in turn may lead to accelerated aging and …

Rotenone, an insecticide that inhibits mitochondrial complex I and generates oxidative
stress, is responsible for neurological disorders and affects the female reproductive system …

Introduction: Oocyte quality and fertility decline with advanced maternal age. During
maturation within the ovarian follicle, the oocyte relies on the associated somatic cells …

The decline in fertility in aging women, especially those with poor ovarian response (POR)
or primary ovarian insufficiency (POI), is a major concern for modern IVF centers. Fertility …

In brief Epigenetic programming is a crucial process during early embryo development that
can have a significant impact on the results of assisted reproductive technology (ART) and …

The overall oocyte quality declines with aging, and this effect is strongly associated with a
higher reactive oxygen species (ROS) level and the resultant oxidative damage. C-type …

The quality of oocytes in patients with polycystic ovary syndrome (PCOS) decreases, which
is closely related to the function of oocytes' mitochondria. If mitochondrial dysfunction is …