Leveraging algal omics to reveal potential targets for augmenting TAG accumulation

N Arora, PT Pienkos, V Pruthi, KM Poluri… - Biotechnology …, 2018 - Elsevier
Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-
omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics …

Metabolic systems biology and multi-omics of cyanobacteria: Perspectives and future directions

R Pathania, A Srivastava, S Srivastava, P Shukla - Bioresource Technology, 2022 - Elsevier
Cyanobacteria are oxygenic photoautotrophs whose metabolism contains key biochemical
pathways to fix atmospheric CO 2 and synthesize various metabolites. The development of …

[PDF][PDF] A hybrid flux balance analysis and machine learning pipeline elucidates metabolic adaptation in cyanobacteria

S Vijayakumar, PKSM Rahman, C Angione - Iscience, 2020 - cell.com
Machine learning has recently emerged as a promising tool for inferring multi-omic
relationships in biological systems. At the same time, genome-scale metabolic models …

Engineering the fatty acid synthesis pathway in Synechococcus elongatus PCC 7942 improves omega-3 fatty acid production

M Santos-Merino, MP Garcillán-Barcia… - Biotechnology for …, 2018 - Springer
Background The microbial production of fatty acids has received great attention in the last
few years as feedstock for the production of renewable energy. The main advantage of using …

CyanoOmicsDB: an integrated omics database for functional genomic analysis of cyanobacteria

P Zhou, L Wang, H Liu, C Li, Z Li, J Wang… - Nucleic Acids …, 2022 - academic.oup.com
With their photosynthetic ability and established genetic modification systems, cyanobacteria
are essential for fundamental and biotechnological research. Till now, hundreds of …

Current perspectives on integrated approaches to enhance lipid accumulation in microalgae

J Rawat, PK Gupta, S Pandit, R Prasad, V Pande - 3 Biotech, 2021 - Springer
In recent years, research initiatives on renewable bioenergy or biofuels have been gaining
momentum, not only due to fast depletion of finite reserves of fossil fuels but also because of …

[HTML][HTML] Protocol for hybrid flux balance, statistical, and machine learning analysis of multi-omic data from the cyanobacterium Synechococcus sp. PCC 7002

S Vijayakumar, C Angione - STAR protocols, 2021 - Elsevier
Combining a computational framework for flux balance analysis with machine learning
improves the accuracy of predicting metabolic activity across conditions, while enabling …

Subtyping of metastatic breast cancer based on plasma circulating tumor DNA alterations: An observational, multicentre platform study

ZY Hu, Y Tang, L Liu, N Xie, C Tian, B Liu, L Zou… - …, 2022 - thelancet.com
Background After multiple lines of therapies, no guideline or consensus is currently
available for the treatment of patients with metastatic breast cancer. This study aims to …

CyanoMapDB: a database integrating experimentally validated protein–protein interactions in cyanobacteria

Z Peng, J Li, X Jiang, C Wan - Plant Physiology, 2023 - academic.oup.com
As one of the essential life forms in the biosphere, research on cyanobacteria has been
growing remarkably for decades. Biological functions in organisms are often accomplished …

Emerging Technologies for the Discovery of Novel Diversity in Cyanobacteria and Algae and the Elucidation of Their Valuable Metabolites

G Zammit, MG Zammit, KG Buttigieg - Diversity, 2023 - mdpi.com
Until recently, the study of cyanobacteria and microalgae has been hampered by the need to
cultivate these organisms to gain insight into their cytomorphology, life cycle and molecular …