The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most
lethal human malignancies. Much is known regarding the biology and pathophysiology of …

The Click Activated Protodrugs Against Cancer (CAPAC) platform enables the activation of
powerful cancer drugs at tumors. CAPAC utilizes a click chemistry reaction between …

The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …

Background The encapsulation of circular RNAs (circRNAs) into extracellular vesicles (EVs)
enables their involvement in intercellular communication and exerts an influence on the …

Abstract Background Both microRNA-21-5p (miR-21) and the tumor microenvironment,
including hypoxia and cancer-associated fibroblasts (CAFs), play a vital role in head and …

Programmed cell death protein 1 (PD-1) inhibitors are the most common immune-checkpoint
inhibitors and considered promising drugs for hepatocellular carcinoma (HCC). However, in …

In recent years, research focused on the multifaceted landscape and functions of cancer-
associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities …

Background A growing number of studies have shown that in addition to adaptive immune
cells such as CD8+ T cells and CD4+ T cells, various other cellular components within …

Breast cancer (BC) is the most frequently diagnosed cancer and one of the major causes of
cancer death. Despite enormous progress in its management, both from the therapeutic and …