A brief survey on the application of metal-catalyzed azide–alkyne cycloaddition reactions to the synthesis of ferrocenyl-x-1, 2, 3-triazolyl-R (x= none or a linker and R …

K Kowalski - Coordination Chemistry Reviews, 2023 - Elsevier
Cancer is one of the leading causes of death worldwide. This review highlights the
importance of metal-catalyzed azide–alkyne cycloaddition reactions in the synthesis of …

Is it still worth renewing nucleoside anticancer drugs nowadays?

ZQ Liu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Highlights•Metabolic procedures of a nucleoside anticancer drug are summarized.•
Anticancer properties of newly synthesized nucleoside analogs are introduced.•Synthetic …

Deciphering the Diversified Metabolic Behavior of Hydroxyalkyl Ferrocidiphenols as Anticancer Complexes

H Wang, X Fan, PP Xie, S Yang, P Pigeon… - Journal of Medicinal …, 2023 - ACS Publications
Ferrocidiphenols possessing appropriate substituents in the aliphatic chain have very
promising anticancer properties, but a systematic approach to deciphering their diversified …

Designing of click-derived 1, 2, 3-triazoles as potential anti-bacterial agents and sensor towards Al (III) ion in aqueous medium

G Singh, Y Thakur, KN Singh, R Yadav… - Inorganic Chemistry …, 2023 - Elsevier
Aluminium is useful in various industrial applications and pharmaceuticals but its excess can
pose serious health risks. There lies a need for the development of simple, cost-effective …

Hydrazones tethered disubstituted 1, 2, 3-triazoles: Design, synthesis, antitubercular and antimicrobial evaluation

A Yadav, CP Kaushik, M Kumar - Journal of Molecular Structure, 2023 - Elsevier
A new series of hydrazones tethered 1, 4-disubstituted 1, 2, 3-triazoles have been
synthesized from novel N-substituted alkynes derived from benzohydrazides and benzyl …

Ruthenium (II)–Arene Complexes with Glycosylated NHC-Carbene Co-Ligands: Synthesis, Hydrolytic Behavior, and Binding to Biological Molecules

A Annunziata, ME Cucciolito, M Di Ronza… - …, 2023 - ACS Publications
Ruthenium (II) complexes with a three-legged piano-stool structure based on an arene ring,
an N-heterocyclic carbene (NHC)-carbene ligand with a peracetylated glucose moiety and …

Structural Modification Strategies of Triazoles in Anticancer Drug Development

Q Guan, Z Gao, Y Chen, C Guo, Y Chen… - European Journal of …, 2024 - Elsevier
The triazole functional group plays a pivotal role in the composition of biomolecules with
potent anticancer activities, including numerous clinically approved drugs. The strategic …

Replacement of the phosphodiester backbone between canonical nucleosides with a dirhenium carbonyl “click” linker—a new class of luminescent organometallic …

J Skiba, A Kowalczyk, A Gorski, N Dutkiewicz… - Dalton …, 2023 - pubs.rsc.org
The first-in-class luminescent dinucleoside phosphate analogs with a [Re2 (μ-Cl) 2 (CO) 6 (μ-
pyridazine)]“click” linker as a replacement for the natural phosphate group are reported …

Post-Functionalization of Organometallic Complexes via Click-Reaction

S Petrovskii, V Khistiaeva, A Paderina, E Abramova… - Molecules, 2022 - mdpi.com
CuAAC (Cu catalyzed azide-alkyne cycloaddition) click-reaction is a simple and powerful
method for the post-synthetic modification of organometallic complexes of transition metals …

Organometallic–Erlotinib Conjugates Active against Lung Cancer Cells and as Emerging Virus Entry Inhibitors

P Biegański, M Gazecka, R Nowak, A Gorski… - …, 2024 - ACS Publications
Conjugation of organometallic entities to drug molecules is a strategy that often results in
products with new biological activity profiles compared to those of their progenitors. In this …