Sex differences in heart failure

G Savarese, D D'Amario - Sex-specific analysis of cardiovascular function, 2018 - Springer
Heart failure (HF) represents a global pandemic health problem with a high impact on health-
care costs, affecting about 26 million adults worldwide. The overall HF prevalence and …

Clinical phenotypes of heart failure with preserved ejection fraction to select preclinical animal models

WB van Ham, EL Kessler, MIFJ Oerlemans… - Basic to Translational …, 2022 - jacc.org
At least one-half of the growing heart failure population consists of heart failure with
preserved ejection fraction (HFpEF). The limited therapeutic options, the complexity of the …

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial …

O Sorop, I Heinonen, M Van Kranenburg… - Cardiovascular …, 2018 - academic.oup.com
Aims More than 50% of patients with heart failure have preserved ejection fraction
characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in …

Heart failure and risk of dementia: a Danish nationwide population‐based cohort study

K Adelborg, E Horváth‐Puhó, A Ording… - European journal of …, 2017 - Wiley Online Library
Aims The association between heart failure and dementia remains unclear. We assessed
the risk of dementia among patients with heart failure and members of a general population …

Trending cardiac biomarkers during pregnancy in women with cardiovascular disease

SA Chang, P Khakh, M Janzen, T Lee… - Circulation: Heart …, 2022 - Am Heart Assoc
Background: Clinical utility of cardiac biomarker testing during pregnancy in women with
preexisting cardiac disease is not well known. We studied the levels and temporal trends of …

[HTML][HTML] Sex differences in cardiovascular outcomes of SGLT-2 inhibitors in heart failure randomized controlled trials: a systematic review and meta-analysis

FB Rivera, VAS Tang, DV De Luna, EV Lerma… - American heart journal …, 2023 - Elsevier
Background In patients with heart failure (HF), randomized controlled trials (RCTs) of sodium-
glucose transporter-2 inhibitors (SGLT-2is) have proven to be effective in decreasing the …

Sex differences in the nutritional status and its association with long-term prognosis in patients with heart failure with reduced ejection fraction: a prospective cohort …

M Kałużna-Oleksy, H Krysztofiak… - European Journal of …, 2024 - academic.oup.com
Aims Many studies show the association between malnutrition and poor prognosis in heart
failure (HF) patients. Our research aimed to analyse sex differences in patients with HF with …

Left atrial strain as a predictor of left ventricular diastolic dysfunction in patients with arterial hypertension

T Miljković, A Ilić, A Milovančev, M Bjelobrk… - Medicina, 2022 - mdpi.com
Background and Objectives: There is emerging evidence of the usefulness of left atrial strain
(LAS) in the assessment of diastolic dysfunction (DD). In this study we assess the sensitivity …

Targeting obesity and diabetes to treat heart failure with preserved ejection fraction

R Altara, M Giordano, ES Nordén, A Cataliotti… - Frontiers in …, 2017 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is a major unmet medical need that is
characterized by the presence of multiple cardiovascular and non-cardiovascular …

[HTML][HTML] Sacubitril/valsartan improves diastolic function but not skeletal muscle function in a rat model of HFpEF

A Schauer, V Adams, A Augstein, A Jannasch… - International Journal of …, 2021 - mdpi.com
The angiotensin receptor/neprilysin inhibitor Sacubitril/Valsartan (Sac/Val) has been shown
to be beneficial in patients suffering from heart failure with reduced ejection fraction (HFrEF) …