An estimated 97% of the human genome consists of non-protein-coding sequences. As our
understanding of genome regulation improves, this has led to the characterization of a …

Despite diagnostic and therapeutic advances, coronary artery disease and especially its
extreme manifestation, ST elevation myocardial infarction (STEMI), remain the leading …

Objective Embolization of carotid stenotic plaques is the direct cause of stroke in nearly 20%
of cases. Genetic mechanisms and especially the roles played by microRNAs in the …

Coronary artery disease (CAD) is the leading cause of sudden cardiac death in adults, and
new methods of predicting disease and risk-stratifying patients will help guide intervention in …

MicroRNA (miR) is reported to be involved in vascular inflammation and may represent a
novel class of diagnostic biomarkers in cardiovascular disease. We aimed to identify the miR …

Cardiovascular diseases are major causes of morbidity and mortality in developed
countries. Cerebrovascular diseases, especially stroke, represent major burden of disability …

Juvenile dermatomyositis (JDM) is a rare autoimmune disease mainly characterized by
muscle and skin involvement. Vasculopathy is considered central to the pathogenesis of the …

Background: MicroRNAs (miRNAs) are endogenous, non-coding, short, single-stranded
RNAs and represent a new class of gene regulators. Recent evidence supports a role for …

The prevalence of atherosclerotic disease continues to increase, and despite significant
reductions in major cardiovascular events with current medical interventions, an additional …

Only recently have we begun to appreciate the importance and complexity of the non-coding
genome, owing in some part to truly significant advances in genomic technology such as …