CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Tumours employ various tactics to adapt and eventually resist immune attack. These
mechanisms are collectively called adaptive immune resistance (AIR). The first defined and …

Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Chimeric antigen receptor (CAR)-T cell-based immunotherapy for cancer and
immunological diseases has made great strides, but it still faces multiple hurdles. Finding …

Conspectus Cancer therapy is routinely performed in the clinic to cure cancer and control its
progression, wherein therapeutic agents are generally used. To reduce side effects …

Improving effector activity of antigen-specific T cells is a major goal in cancer
immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …

Strategies of improving vaccine targeting ability toward lymph nodes have been attracting
considerable interest in recent years, though there are remaining delivery barriers based on …

Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here
report on a human antigen-specific ex vivo model to explore new therapeutic options for T …

Glioblastoma (GBM) contains self-renewing GBM stem cells (GSC) potentially amenable to
immunologic targeting, but chimeric antigen receptor (CAR) T-cell therapy has demonstrated …

Biological molecules such as DNA, proteins, and lipids can be assembled into naturally
existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages) …