Regulation of Nrf2—an update
SK Niture, R Khatri, AK Jaiswal - Free Radical Biology and Medicine, 2014 - Elsevier
Abstract Nrf2: INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is
a nuclear factor that controls the expression and coordinated induction of a battery of genes …
a nuclear factor that controls the expression and coordinated induction of a battery of genes …
Nrf2: INrf2 (Keap1) signaling in oxidative stress
JW Kaspar, SK Niture, AK Jaiswal - Free Radical Biology and Medicine, 2009 - Elsevier
Nrf2: INrf2 (Keap1) are cellular sensors of chemical-and radiation-induced oxidative and
electrophilic stress. Nrf2 is a nuclear transcription factor that controls the expression and …
electrophilic stress. Nrf2 is a nuclear transcription factor that controls the expression and …
Risk to human health related to the presence of perfluoroalkyl substances in food
EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …
Adaptive response to oxidative stress: Bacteria, fungi, plants and animals
VI Lushchak - Comparative Biochemistry and Physiology Part C …, 2011 - Elsevier
Reactive oxygen species (ROS) are continuously produced and eliminated by living
organisms normally maintaining ROS at certain steady-state levels. Under some …
organisms normally maintaining ROS at certain steady-state levels. Under some …
Xenobiotic, bile acid, and cholesterol transporters: function and regulation
CD Klaassen, LM Aleksunes - Pharmacological reviews, 2010 - ASPET
Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance
SA Rushworth, L Zaitseva, MY Murray… - Blood, The Journal …, 2012 - ashpublications.org
Abstract NF-E2–related factor 2 (Nrf2) transcription factor regulates a range of cytoprotective
transcriptional responses, preventing further cellular injury by removing biochemical …
transcriptional responses, preventing further cellular injury by removing biochemical …
Nrf2 signaling and cell survival
SK Niture, JW Kaspar, J Shen, AK Jaiswal - Toxicology and applied …, 2010 - Elsevier
Nrf2: INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to
link Nrf2 to the ubiquitin ligase Cul3–Rbx1 complex that ubiquitinate and degrade Nrf2 …
link Nrf2 to the ubiquitin ligase Cul3–Rbx1 complex that ubiquitinate and degrade Nrf2 …
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling
MB Rosen, KP Das, J Rooney, B Abbott, C Lau… - Toxicology, 2017 - Elsevier
Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants.
Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane sulfonate (PFOS) …
Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane sulfonate (PFOS) …
Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice
LM Aleksunes, CD Klaassen - Drug Metabolism and Disposition, 2012 - ASPET
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor
(CAR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor α (PPARα) …
(CAR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor α (PPARα) …
5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers
PIK3CA encodes the p110α catalytic subunit of PI3K and is frequently mutated in human
cancers, including∼ 30% of colorectal cancer. Oncogenic mutations in PIK3CA render …
cancers, including∼ 30% of colorectal cancer. Oncogenic mutations in PIK3CA render …