Bone tissue engineering scaffolds: function of multi‐material hierarchically structured scaffolds

TM Koushik, CM Miller… - Advanced healthcare …, 2023 - Wiley Online Library
Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in
materials, processing techniques, and the understanding of bone healing pathways have …

Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling

KH Griffin, SW Fok, J Kent Leach - NPJ Regenerative Medicine, 2022 - nature.com
Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …

Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration

FV Ferreira, LP Souza, TMM Martins, JH Lopes… - Nanoscale, 2019 - pubs.rsc.org
A major challenge exists in the preparation of scaffolds for bone regeneration, namely,
achieving simultaneously bioactivity, biocompatibility, mechanical performance and simple …

Vanillin-bioglass cross-linked 3D porous chitosan scaffolds with strong osteopromotive and antibacterial abilities for bone tissue engineering

J Hu, Z Wang, JM Miszuk, M Zhu, TI Lansakara… - Carbohydrate …, 2021 - Elsevier
Chitosan scaffolds crosslinked by current methods insufficiently meet the demands of bone
tissue engineering applications. We developed a novel effective crosslinking technique by …

Mesoporous bioactive glasses for bone healing and biomolecules delivery

V Lalzawmliana, A Anand, M Roy, B Kundu… - Materials Science and …, 2020 - Elsevier
Impact of bone diseases and injury is increasing at an enormous rate during the past
decades due to increase in road traffic accidents and other injuries. Bioactive glasses have …

Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accelerate bone regeneration in …

RM Raftery, IM Castaño, G Chen, B Cavanagh… - Biomaterials, 2017 - Elsevier
The clinical translation of bioactive scaffolds for the treatment of large segmental bone
defects has remained a challenge due to safety and efficacy concerns as well as prohibitive …

Prevascularization of 3D printed bone scaffolds by bioactive hydrogels and cell co‐culture

MA Kuss, S Wu, Y Wang, JB Untrauer… - … Research Part B …, 2018 - Wiley Online Library
Vascularization is a fundamental prerequisite for large bone construct development and
remains one of the main challenges of bone tissue engineering. Our current study presents …

Spheroids as vascularization units: From angiogenesis research to tissue engineering applications

MW Laschke, MD Menger - Biotechnology advances, 2017 - Elsevier
Multi-cellular spheroids mimic the complex three-dimensional environment of natural
tissues. Accordingly, they are also used as vascularization units in angiogenesis research …

Enhanced osteogenesis and angiogenesis by PCL/chitosan/Sr-doped calcium phosphate electrospun nanocomposite membrane for guided bone regeneration

H Ye, J Zhu, D Deng, S Jin, J Li… - Journal of Biomaterials …, 2019 - Taylor & Francis
Membranes play pivotal role in guided bone regeneration (GBR) technique for
reconstruction alveolar bone. GBR membrane that is able to stimulate both osteogenic and …

Microfluidic fabrication of microcarriers with sequential delivery of VEGF and BMP-2 for bone regeneration

E Dashtimoghadam, F Fahimipour, N Tongas… - Scientific Reports, 2020 - nature.com
Wound instability and poor functional vascularization in bone tissue engineering lead to lack
of tissue integration and ultimate failure of engineered grafts. In order to harness the …