Applications of CRISPR-Cas systems in lactic acid bacteria

A Roberts, R Barrangou - FEMS Microbiology Reviews, 2020 - academic.oup.com
As a phenotypically and phylogenetically diverse group, lactic acid bacteria are found in a
variety of natural environments and occupy important roles in medicine, biotechnology, food …

Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models

NT Devika, K Raman - Scientific Reports, 2019 - nature.com
Bifidobacteria, the initial colonisers of breastfed infant guts, are considered as the key
commensals that promote a healthy gastrointestinal tract. However, little is known about the …

Glycan cross-feeding activities between bifidobacteria under in vitro conditions

F Turroni, E Özcan, C Milani, L Mancabelli… - Frontiers in …, 2015 - frontiersin.org
Bifidobacteria colonize the gut of various mammals, including humans, where they may
metabolize complex, diet-, and host-derived carbohydrates. The glycan-associated …

The sortase-dependent fimbriome of the genus Bifidobacterium: extracellular structures with potential to modulate microbe-host dialogue

C Milani, M Mangifesta, L Mancabelli… - Applied and …, 2017 - Am Soc Microbiol
Bifidobacteria are important gut commensals of mammals, including humans, of any age.
However, the molecular mechanisms by which these microorganisms establish themselves …

Probiotic characters of Bifidobacterium and Lactobacillus are a result of the ongoing gene acquisition and genome minimization evolutionary trends

M Papizadeh, M Rohani, H Nahrevanian, A Javadi… - Microbial …, 2017 - Elsevier
Bifidobacterium and Lactobacillus are the main probiotic genera. Collectively, these two
genera harbor over 200 species among which are many strains have been introduced as …

Evolutionary relationships among bifidobacteria and their hosts and environments

CI Rodriguez, JBH Martiny - BMC genomics, 2020 - Springer
Background The assembly of animal microbiomes is influenced by multiple environmental
factors and host genetics, although the relative importance of these factors remains unclear …

Prophages of the genus Bifidobacterium as modulating agents of the infant gut microbiota

GA Lugli, C Milani, F Turroni… - Environmental …, 2016 - Wiley Online Library
Phage predation is one of the key forces that shape genetic diversity in bacterial genomes.
Phages are also believed to act as modulators of the microbiota composition and …

Bacterial folate biosynthesis and colorectal cancer risk: more than just a gut feeling

DE Kok, WT Steegenga, EJ Smid… - Critical reviews in …, 2020 - Taylor & Francis
Folate is a B-vitamin with an important role in health and disease. The optimal folate status
with regard to human health remains controversial. A low intake of natural folate as well as …

Characterization and Exploitation of CRISPR Loci in Bifidobacterium longum

C Hidalgo-Cantabrana, AB Crawley… - Frontiers in …, 2017 - frontiersin.org
Diverse CRISPR-Cas systems provide adaptive immunity in many bacteria and most
archaea, via a DNA-encoded, RNA-mediated, nucleic-acid targeting mechanism. Over time …

Insights from genomes of representatives of the human gut commensal Bifidobacterium bifidum

S Duranti, C Milani, GA Lugli, F Turroni… - Environmental …, 2015 - Wiley Online Library
Bifidobacteria are bacterial gut commensals of mammals, birds and social insects that are
perceived to influence the metabolism/physiology of their host. In this context, members of …