The role of ROS in tumour development and progression

EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches

TB Emran, A Shahriar, AR Mahmud, T Rahman… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Ligand-engineered bandgap stability in mixed-halide perovskite LEDs

Y Hassan, JH Park, ML Crawford, A Sadhanala, J Lee… - Nature, 2021 - nature.com
Lead halide perovskites are promising semiconductors for light-emitting applications
because they exhibit bright, bandgap-tunable luminescence with high colour purity …

The antioxidant glutathione

DA Averill-Bates - Vitamins and hormones, 2023 - Elsevier
Reduced glutathione (GSH) is an essential non-enzymatic antioxidant in mammalian cells.
GSH can act directly as an antioxidant to protect cells against free radicals and pro-oxidants …

Glutathione-related enzymes and proteins: a review

J Vašková, L Kočan, L Vaško, P Perjési - Molecules, 2023 - mdpi.com
The tripeptide glutathione is found in all eukaryotic cells, and due to the
compartmentalization of biochemical processes, its synthesis takes place exclusively in the …

[PDF][PDF] Oxidative stress and antioxidant mechanisms in human body

AA Adwas, A Elsayed, AE Azab… - J. Appl. Biotechnol …, 2019 - academia.edu
The present review aims to high light on the oxidative stress, and prevention by internal
antioxidants and external antioxidants by some natural products possessing antioxidant …

Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)

K Xu, Y Zhang, Y Huang, J Wang - Science of The Total Environment, 2021 - Elsevier
The toxicology of microplastics in combination with other pollutants has attracted
widespread attention. In this study, zebrafish were exposed to 3 mg/L polystyrene …

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …

LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Oxidative stress response and Nrf2 signaling in aging

H Zhang, KJA Davies, HJ Forman - Free Radical Biology and Medicine, 2015 - Elsevier
Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

KO Alfarouk, CM Stock, S Taylor, M Walsh… - Cancer cell …, 2015 - Springer
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …