The role of ROS in tumour development and progression
EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
Ligand-engineered bandgap stability in mixed-halide perovskite LEDs
Lead halide perovskites are promising semiconductors for light-emitting applications
because they exhibit bright, bandgap-tunable luminescence with high colour purity …
because they exhibit bright, bandgap-tunable luminescence with high colour purity …
The antioxidant glutathione
DA Averill-Bates - Vitamins and hormones, 2023 - Elsevier
Reduced glutathione (GSH) is an essential non-enzymatic antioxidant in mammalian cells.
GSH can act directly as an antioxidant to protect cells against free radicals and pro-oxidants …
GSH can act directly as an antioxidant to protect cells against free radicals and pro-oxidants …
Glutathione-related enzymes and proteins: a review
The tripeptide glutathione is found in all eukaryotic cells, and due to the
compartmentalization of biochemical processes, its synthesis takes place exclusively in the …
compartmentalization of biochemical processes, its synthesis takes place exclusively in the …
[PDF][PDF] Oxidative stress and antioxidant mechanisms in human body
The present review aims to high light on the oxidative stress, and prevention by internal
antioxidants and external antioxidants by some natural products possessing antioxidant …
antioxidants and external antioxidants by some natural products possessing antioxidant …
Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
K Xu, Y Zhang, Y Huang, J Wang - Science of The Total Environment, 2021 - Elsevier
The toxicology of microplastics in combination with other pollutants has attracted
widespread attention. In this study, zebrafish were exposed to 3 mg/L polystyrene …
widespread attention. In this study, zebrafish were exposed to 3 mg/L polystyrene …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
Oxidative stress response and Nrf2 signaling in aging
H Zhang, KJA Davies, HJ Forman - Free Radical Biology and Medicine, 2015 - Elsevier
Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …
of age-related pathologies. In aging, oxidant production from several sources is increased …
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
KO Alfarouk, CM Stock, S Taylor, M Walsh… - Cancer cell …, 2015 - Springer
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …