MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity. In
normal cells the MDM2 protein binds to the p53 protein and maintains p53 at low levels by …

Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53
has widened to include the sensing of much more diverse forms of stress, including hypoxia …

The fifth component of the COP9 signalosome complex, Jab1/CSN5, directly binds to and
induces specific down-regulation of the cyclin-dependent kinase inhibitor p27 (p27 Kip1) …

The alternative product of the human INK4a/ARF locus, p14 ARF, has the potential to act as
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …

The Saccharomyces cerevisiae chromatin silencing factor Sir2 suppresses genomic
instability and extends replicative life span. In contrast, we find that mouse embryonic …

The INK4a-ARF locus encodes two tumor suppressor proteins involved in cell-cycle
regulation, p16 INK4a and p14 ARF, whose functions are inactivated in many human …

Jab1 interacts with a variety of signaling molecules and regulates their stability in
mammalian cells. As the fifth component of the COP9 signalosome (CSN) complex, Jab1 …

The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …

Although overexpression of E2F-1 can induce apoptosis in a variety of tumor cell lines, the
mechanisms by which E2F-1 induces apoptosis remain ambiguous. In this study, we …

The transcription factor E2F plays an important role in G 1 to S phase transition in the higher
eukaryotic cell cycle. Although a number of E2F-inducible genes have been identified, the …