All organisms can sense O2 concentration and respond to hypoxia with adaptive changes in
gene expression. The large body size of mammals necessitates the development of multiple …

Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factor
(HIF), a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator …

Mammalian cells adapt to hypoxic conditions through a transcriptional response pathway
mediated by the hypoxia-inducible factor, HIF. HIF transcriptional activity is suppressed …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …

▪ Abstract Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS
transcription factor consisting of HIF-1α and HIF-1β subunits. HIF-1α expression and HIF-1 …

The increase in body size of humans and other vertebrates requires a physiological
infrastructure to provide adequate delivery of oxygen to tissues and cells to maintain oxygen …

The hypoxia-inducible factors (HIFs) 1α and 2α are key mammalian transcription factors that
exhibit dramatic increases in both protein stability and intrinsic transcriptional potency during …

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …

SUMMARY PAS domains are newly recognized signaling domains that are widely
distributed in proteins from members of the Archaea and Bacteria and from fungi, plants …

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential
homeostatic responses to reduced O2 availability in mammals. Recent studies have …