Hypoxia-inducible factor 1 (HIF-1) is a transcription factor involved in normal mammalian
development and in the pathogenesis of several disease states. It consists of two subunits …

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that mediates
adaptive responses to hypoxia. We demonstrate that lysosomal degradation of the HIF-1α …

Purpose: RNA interference mediated by small interfering RNAs (siRNAs) is a powerful
technology allowing the silencing of mamalian genes with great specificity and potency. The …

Oxygen is essential to the life of all aerobic organisms. Virtually every cell type is able to
sense a limited oxygen supply (hypoxia) and specifically to induce a set of oxygen-regulated …

Hypoxia-inducible factors (HIF) are a family of heterodimeric transcriptional regulators that
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …

The brain, which represents 2% of body mass but consumes 20% of body energy at rest, has
a limited capacity to store energy and is therefore highly dependent on oxygen and glucose …

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor activated by hypoxia. The HIF-1
activation transduction pathway is poorly understood. In this report, we investigated the …

Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that
play key roles in breast cancer biology. We hypothesized that interaction of HIF-1 with …

The idea of antiangiogenic therapy was the brainchild of D r. J udah F olkman in the early
1970s. He proposed that by cutting off the blood supply, cancer cells would be deprived of …

IN HUMANS AND OTHER mammals, decreased oxygen tension triggers specific and tightly
regulated cellular, vascular, and erythropoietic responses. An association between …