It has been shown that oxygen deprivation results in apoptotic cell death, and that hypoxia
inducible factor 1 (HIF1) and the tumor suppressor p53 play key roles in this process …

The idea of antiangiogenic therapy was the brainchild of D r. J udah F olkman in the early
1970s. He proposed that by cutting off the blood supply, cancer cells would be deprived of …

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a
number of adaptive responses to low oxygen tension. They are composed of α-and β …

The elucidation of the molecular mechanisms governing the transition from a nonangiogenic
to an angiogenic phenotype is central for understanding and controlling malignancies. Viral …

Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the
transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 …

Breast cancer is the most common cancer in women worldwide with increasing incidence.
Significant therapeutics advances in the field of breast cancer have resulted in a growing …

Abstract Cyclooxygenase (COX)-2, the inducible key enzyme for prostanoid biosynthesis, is
overexpressed in most colorectal carcinomas and a subset of colorectal adenomas. Genetic …

Tumor hypoxia was first described in the 1950s by radiation oncologists as a frequent cause
of failure to radiotherapy in solid tumors. Today, it is evident that tumor hypoxia is a common …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

Oxygen homeostasis is a cornerstone of both the physiology and intermediary metabolism
systems. Despite the explosion of knowledge brought about by recombinant DNA …