Epidermal growth factor receptor is a trans-membrane glycoprotein with an extracellular
epidermal growth factor binding domain and an intracellular tyrosine kinase domain that …

Non-small cell lung cancer (NSCLC) tumours with certain mutations in the epidermal growth
factor receptor (EGFR) tyrosine kinase have been termed 'oncogene addicted'to reflect their …

User-friendly and concise, the new edition of this popular reference is your# 1 guide for the
appropriate use of immunohistochemical stains. Dr. David J. Dabbs and leading experts in …

Purpose To investigate the prognostic role of genomic gain for MET and epidermal growth
factor receptor (EGFR) genes in surgically resected non–small-cell lung cancer (NSCLC) …

Purpose Programmed cell death-1 (PD-1)/programmed cell death-ligand-1 (PD-L1) pathway-
targeted immunotherapy has beneficial therapeutic effects in pulmonary squamous cell …

Immunotherapies targeting the programmed cell death-1/programmed cell death-ligand 1
pathway have emerged as promising therapeutic strategies for lung cancer. However, the …

Introduction Activation of MET, either by increased gene copy number (GCN) or mutation,
has been detected in various cancers. We investigate the clinicopathologic features of MET …

Purpose To retrospectively identify quantitative computed tomographic (CT) features that
correlate with epidermal growth factor receptor (EGFR) mutation in surgically resected lung …

Background Central nervous system is a common site of metastasis in NSCLC and confers
worse prognosis and quality of life. The aim of this prospective study was to evaluate the …

Tumor microenvironment plays a critical role in tumor initiation and progression.
Components in the microenvironment can modulate the growth of tumor cells, their ability to …