Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To
understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic …

HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes
(HNF1A–maturity onset diabetes of the young [HNF1A-MODY]), and hypomorphic HNF1A …

Understanding the factors and mechanisms involved in beta-cell development will guide
therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) …

Missense variants are the most common type of coding genetic variants. Their functional
assessment is fundamental for defining any implication in human diseases and may also …

Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism
is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α …

Animal longevity is a function of global vital organ functionality and, consequently, a
complex polygenic trait. Yet, monogenic regulators controlling overall or organ-specific …

Genome wide association studies (GWAS) have identified over 100 signals associated with
type 1 diabetes (T1D). However, translating any given T1D GWAS signal into mechanistic …

Diabetes mellitus, a significant global public health challenge, severely impacts human
health worldwide. The organoid, an innovative in vitro three-dimensional (3D) culture model …