Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily
conserved serine/threonine kinase that was originally identified as the key player in …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …

Mitochondria are unique and essential organelles that mediate many vital cellular processes
including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45 …

Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating
the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and …

The mammalian kidney relies on abundant mitochondria in the renal tubule to generate
sufficient ATP to provide the energy required for constant reclamation of solutes from crude …

Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …