Hepatic lipid metabolism is a series of complex processes that control influx and efflux of not
only hepatic lipid pools, but also organismal pools. Lipid homeostasis is usually tightly …

Obesity is a global health problem that affects all age groups in both developing and
developed countries. In recent years, the prevalence of overweight and obesity has reached …

Recent studies have indicated that the regulation of innate immunity and energy metabolism
are connected together through an antagonistic crosstalk between NF-κB and SIRT1 …

AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and …

Insulin resistance (IR) and hyperinsulinemia are hallmarks of the metabolic syndrome, as
are central adiposity, dyslipidemia, and a predisposition to type 2 diabetes, atherosclerotic …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic
organelles or cytosolic components. This pathway can be stimulated by multiple forms of …

Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell
dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have …

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

Autophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular
metabolic demands by removal of the damaged molecules and organelles and for …