Induction of heat shock protein (HSP) 72 protects against obesity-induced insulin resistance,
but the underlying mechanisms are unknown. Here, we show that HSP72 plays a pivotal …

Hyaluronan (HA) is a linear glycosaminoglycan (GAG) of extracellular matrix (ECM)
synthesized by three hyaluronan synthases (HASes) at the plasma membrane using uridine …

Amino acids not only participate in intermediary metabolism but also stimulate insulin-
mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the …

Aim. Despite the beneficial effects of dietary restriction (DR) on lifespan, age‐related
diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic …

Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive,
antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a …

Almost a half century ago, the free radical theory of ageing proposed that the reactive
oxygen species (ROS) is a key component which contributes to the pathophysiology of …

Metabolic syndrome is a low-grade inflammatory state in which oxidative stress is involved.
Naringin, isolated from the Citrussinensis, is a phenolic compound with anti-oxidative and …

Diabetic mellitus (DM) is a significant public health concern worldwide with an increased
incidence of morbidity and mortality, which is particularly due to the diabetic vascular …

Background Platinum based agents—cisplatin and carboplatin in combination with taxanes
are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC …

Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as
hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha‐lipoic acid (α …