Last year, ipilimumab (Yervoy; Bristol-Myers Squibb, New York, NY) was approved by the
Food and Drug Administration (FDA) for the treatment of metastatic melanoma. The benefit …

Neoadjuvant therapy is increasingly used to treat patients with a wide variety of
malignancies. Histologic evaluation of treated specimens provides important prognostic …

In recent years, esophageal cancer characteristics and management options have evolved
significantly. There has been a sharp increase in the frequency of esophageal …

Objective Endoscopic surveillance of Barrett's oesophagus (BO) provides an opportunity to
detect early stage oesophageal adenocarcinoma (OAC). We sought to determine the …

Purpose: We examined the frequency, tumor characteristics, and prognostic impact of HER2
protein expression and gene amplification in patients with curatively resected esophageal …

Purpose There is increasing recognition of the existence of intratumoral heterogeneity of the
human epidermal growth factor receptor (HER2), which affects interpretation of HER2 …

Although signet ring cell cancer (SRCC) has long been regarded as an adverse prognostic
factor of gastric cancer, the findings of existing studies on this issue are inconsistent. We …

Purpose Given that smoking affects body mass index (BMI) and survival, stratification by
smoking status may be required to determine the true prognostic impact of BMI. Although …

BACKGROUND Human epidermal growth factor receptor 2 (HER2) is a therapeutic target in
patients with esophageal adenocarcinoma (EAC), with gene amplification used as a …

BACKGROUND Signet ring cell esophageal adenocarcinoma histology has been difficult to
study in single institution series because of its relative rarity, yet has an anecdotal reputation …