Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

M Kolarikova, B Hosikova, H Dilenko… - Medicinal Research …, 2023 - Wiley Online Library
Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial
infections. This treatment dates back to 1900 when a German medical school graduate …

Organelle-targeted photosensitizers for precision photodynamic therapy

R Wang, X Li, J Yoon - ACS Applied Materials & Interfaces, 2021 - ACS Publications
Subcellular organelles are the cornerstones of cells, and destroying them will cause cell
dysfunction and even death. Therefore, realizing precise organelle targeting of …

Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications

J Zielonka, J Joseph, A Sikora, M Hardy… - Chemical …, 2017 - ACS Publications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

J Yang, A Griffin, Z Qiang, J Ren - Signal transduction and targeted …, 2022 - nature.com
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

P Shi, Z Cheng, K Zhao, Y Chen, A Zhang… - Journal of …, 2023 - Springer
Osteosarcoma, the most common malignant tumor of the bone, seriously influences people's
lives and increases their economic burden. Conventional chemotherapy drugs achieve …

Smart Design of Nanomaterials for Mitochondria‐Targeted Nanotherapeutics

SS Liew, X Qin, J Zhou, L Li, W Huang… - Angewandte Chemie …, 2021 - Wiley Online Library
Mitochondria are the powerhouse of cells. They are vital organelles that maintain cellular
function and metabolism. Dysfunction of mitochondria results in various diseases with a …

Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics

Z Ma, H Han, Y Zhao - Biomaterials, 2023 - Elsevier
Mitochondria play critical roles in the regulation of the proliferation and apoptosis of
cancerous cells. Targeted induction of mitochondrial dysfunction in cancer cells by …

Subcellular visualization: organelle-specific targeted drug delivery and discovery

X Shao, C Meng, W Song, T Zhang, Q Chen - Advanced Drug Delivery …, 2023 - Elsevier
Organelles perform critical biological functions due to their distinct molecular composition
and internal environment. Disorders in organelles or their interacting networks have been …

The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy

S Liu, AR Khan, X Yang, B Dong, J Ji, G Zhai - Journal of Controlled …, 2021 - Elsevier
Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists
have considered the overexpressed efflux transporters responsible for MDR and …