[HTML][HTML] Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
[HTML][HTML] COVID-19 and the role of cytokines in this disease
A Hasanvand - Inflammopharmacology, 2022 - Springer
Studies have shown that SARS-CoV-2 has the ability to activate and mature proinflammatory
cytokines in the body. Cytokine markers are a group of polypeptide signalling molecules that …
cytokines in the body. Cytokine markers are a group of polypeptide signalling molecules that …
[HTML][HTML] A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts
J Chen, JA Neil, JP Tan, R Rudraraju, M Mohenska… - Nature Cell …, 2023 - nature.com
SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19
during pregnancy to negative birth outcomes and placentitis. However, the …
during pregnancy to negative birth outcomes and placentitis. However, the …
The structure-based design of SARS-CoV-2 nsp14 methyltransferase ligands yields nanomolar inhibitors
T Otava, M Sala, F Li, J Fanfrlik, K Devkota… - ACS infectious …, 2021 - ACS Publications
In this study, we have focused on the structure-based design of the inhibitors of one of the
two SARS-CoV-2 methyltransferases (MTases), nsp14. This MTase catalyzes the transfer of …
two SARS-CoV-2 methyltransferases (MTases), nsp14. This MTase catalyzes the transfer of …
[HTML][HTML] Cytokine storm syndrome in SARS-CoV-2 infections: a functional role of mast cells
Cytokine storm syndrome is a cascade of escalated immune responses disposing the
immune system to exhaustion, which might ultimately result in organ failure and fatal …
immune system to exhaustion, which might ultimately result in organ failure and fatal …
[HTML][HTML] Viral proteases as therapeutic targets
T Majerová, J Konvalinka - Molecular Aspects of Medicine, 2022 - Elsevier
Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …
herpesviruses―code for a protease, which is indispensable for viral maturation and …
[HTML][HTML] Repurposing the estrogen receptor modulator raloxifene to treat SARS-CoV-2 infection
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates strategies to identify …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates strategies to identify …
[HTML][HTML] Deciphering the relationship between SARS-CoV-2 and cancer
M Costanzo, MAR De Giglio, GN Roviello - International Journal of …, 2023 - mdpi.com
Some viruses are known to be associated with the onset of specific cancers. These
microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer …
microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer …
[HTML][HTML] A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: A therapeutic approach to inflammation
MC Domínguez-Horta, A Serrano-Díaz… - Frontiers in …, 2023 - frontiersin.org
Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They
are crucial in the progress of acute inflammatory diseases and autoimmunity. In fact, the …
are crucial in the progress of acute inflammatory diseases and autoimmunity. In fact, the …
[HTML][HTML] Mediterranean diet for the prevention of gestational diabetes in the Covid-19 era: implications of Il-6 in diabesity
AL Fedullo, A Schiattarella, M Morlando… - International journal of …, 2021 - mdpi.com
The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on
Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID …
Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID …