Glucocorticoids (GCs) are the most potent anti-inflammatory agents known. A major factor
limiting their clinical use is the wide variation in responsiveness to therapy. The high doses …

Glucocorticoids (GCs) have powerful and potent anti‐inflammatory and immunomodulatory
effects in rheumatoid arthritis (RA) and many other diseases. These effects are mediated by …

The MDR1 gene is an attractive candidate gene for the pathogenesis of inflammatory bowel
disease (IBD) and perhaps response to therapy, with evidences at both functional and …

Crohn's disease is a lifelong illness characterized by chronic recurrent flares. The precise
etiology of Crohn's disease is unknown. However, it appears to involve an enhanced …

One of the major challenges in IBD therapy is targeting delivery of the drug to the specific
site of inflammation. A recent approach to combat this problem is the use of nanoparticulate …

Sepsis is an acute systemic inflammatory disease. Glucocorticoids (GCs), which function by
binding to the GC receptor GR have very powerful anti-inflammatory activities, yet they are …

This review describes the pharmacokinetics of the major drugs used for the treatment of
inflammatory bowel disease. This information can be helpful for the selection of a particular …

Linked to the growing obesity epidemic, demand for bariatric and metabolic surgery has
increased, the most common procedures being sleeve gastrectomy and Roux-en-Y gastric …

BACKGROUND & AIMS: Comparative data on budesonide vs mesalamine for the treatment
of mild-to-moderately active Crohn's disease (CD) are sparse. We assessed the efficacy and …

Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases
including asthma and chronic obstructive pulmonary disease (COPD). However, it has been …