Background Oral squamous cell carcinoma (OSCC) accounts over 90% of malignant
neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate …

Different modes of cell death regulate immunity. Whereas necrotic (necroptotic, pyroptotic)
cell death triggers inflammation, apoptosis contributes to its resolution. Interleukin-1 (IL-1) …

Macrophages are a group of heterogeneous cells of the innate immune system that are
crucial to the initiation, progression, and resolution of inflammation. Moreover, they control …

IL-4 induces Akt activation in macrophages, required for full M2 (alternative) polarization. We
examined the roles of Gαi1 and Gαi3 in M2 polarization using multiple genetic methods …

Background Reperfusion therapy is the most effective approach to resolve coronary
occlusion, but myocardial injury caused by excessive inflammation during myocardial …

Mycobacterium tuberculosis (MTB) infection could induce death of host human
macrophages, promoting bacterial spread. In the current study we tested the potential role of …

Mycobacterium tuberculosis (MTB) infection induces cytotoxicity to host human
macrophages. The underlying signaling mechanisms are largely unknown. Here we …

Mycobacterium tuberculosis (MTB) infection can induce cytotoxicity to the host
macrophages, promoting bacterial spread. We here tested the potential effect of oltipraz, a …

Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in
cancer pathophysiology in several ways, including tumor growth and progression …

Background T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a vital
immune checkpoint that regulates the immune response. However, the specific role of TIM3 …