A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy
The identification of molecular agents inhibiting specific functions in cancer cells
progression is considered as one of the most successful plans in cancer treatment. The …
progression is considered as one of the most successful plans in cancer treatment. The …
[HTML][HTML] Molecular targets and anticancer activity of quinoline–chalcone hybrids: Literature review
MFA Mohamed, GEDA Abuo-Rahma - RSC advances, 2020 - pubs.rsc.org
α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …
medicinal chemistry, especially in the identification and development of potential anticancer …
[HTML][HTML] Review on recent development of quinoline for anticancer activities
M Ilakiyalakshmi, AA Napoleon - Arabian Journal of Chemistry, 2022 - Elsevier
Quinoline is an efficient scaffold for anticancer drug development as its derivatives have
shown potent results through several mechanisms like growth regulators through “apoptosis …
shown potent results through several mechanisms like growth regulators through “apoptosis …
[HTML][HTML] Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review
Lung cancer is the second most common cause of morbidity and mortality among cancer
types worldwide, with non-small cell lung cancer (NSCLC) representing the majority of most …
types worldwide, with non-small cell lung cancer (NSCLC) representing the majority of most …
Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents
SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
[HTML][HTML] Quinoline-based molecules targeting c-Met, EGF, and VEGF receptors and the proteins involved in related carcinogenic pathways
The quinoline ring system has long been known as a versatile nucleus in the design and
synthesis of biologically active compounds. Currently, more than one hundred quinoline …
synthesis of biologically active compounds. Currently, more than one hundred quinoline …
Design, synthesis and biological evaluation of novel benzo-and tetrahydrobenzo-[h] quinoline derivatives as potential DNA-intercalating antitumor agents
F Jafari, H Baghayi, P Lavaee, F Hadizadeh… - European journal of …, 2019 - Elsevier
A new series of benzo-and tetrahydro benzo-[h] quinoline bearing a flexible (dimethylamino)
ethylcarboxamide side chain was designed and synthesized as DNA-intercalating antitumor …
ethylcarboxamide side chain was designed and synthesized as DNA-intercalating antitumor …
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
Quinoline: an attractive scaffold in drug design
LFE Moor, TRA Vasconcelos… - Mini Reviews in …, 2021 - ingentaconnect.com
Quinoline and its derivatives comprise an important group of heterocyclic compounds that
exhibits a wide range of pharmacological properties such as antibacterial, antiviral …
exhibits a wide range of pharmacological properties such as antibacterial, antiviral …
Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors
MS Abdelbaset, M Abdel-Aziz, M Ramadan… - Bioorganic & Medicinal …, 2019 - Elsevier
Novel thienoquinoline carboxamide-chalcone derivatives were prepared via the cyclization
of acylated chalcones and 2-mercaptoquinoline-3-carbaldehyde in DMF with K 2 CO 3 …
of acylated chalcones and 2-mercaptoquinoline-3-carbaldehyde in DMF with K 2 CO 3 …