Air pollution and the airways: lessons from a century of human urbanization

J Goossens, AC Jonckheere, LJ Dupont, DMA Bullens - Atmosphere, 2021 - mdpi.com
Since the industrial revolution, air pollution has become a major problem causing several
health problems involving the airways as well as the cardiovascular, reproductive, or …

[HTML][HTML] Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease

A Dobric, SN De Luca, SJ Spencer, S Bozinovski… - Pharmacology & …, 2022 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden
and currently the 3rd largest cause of death in the world, with approximately 3.23 million …

ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK …

B He, Y Wu, W Hu, J Hua, Y Han, J Zhang - Free Radical Biology and …, 2023 - Elsevier
Cigarette smoking (CS) exposure-induced airway inflammatory responses drive the
occurrence and development of emphysema and chronic obstructive pulmonary disease …

[HTML][HTML] Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke–induced severe flu

TW Kaminski, T Brzoska, X Li, R Vats, O Katoch… - JCI insight, 2024 - ncbi.nlm.nih.gov
Cigarette smoking is associated with a higher risk of ICU admissions among patients with
flu. However, the etiological mechanism by which cigarette smoke (CS) exacerbates flu …

Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice

Y Dai, K Duan, G Huang, X Yang, X Jiang… - Frontiers in …, 2023 - frontiersin.org
Electronic cigarettes have become increasingly popular, but the results of previous studies
on electronic cigarette exposure in animals have been equivocal. This study aimed to …

Role and mechanisms of autophagy in lung metabolism and repair

X Li, F Zhao, A Wang, P Cheng, H Chen - Cellular and Molecular Life …, 2021 - Springer
Mammalian lungs are metabolically active organs that frequently encounter environmental
insults. Stress responses elicit protective autophagy in epithelial barrier cells and the …

Role of autoimmunity in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema

F Nucera, PM Hansbro, KR Paudel, V Casolaro… - Translational …, 2022 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality. Cigarette
smoke is the cause of COPD. However, only a fraction of current and/or former smokers …

Brain Glucose Metabolism as a Readout of the Central Nervous System Impact of Cigarette Smoke Exposure and Withdrawal and the Effects of NFL-101, as an …

S Goutal, T Tran, C Leroy, N Benhamouda… - ACS Chemical …, 2024 - ACS Publications
Neuroimaging biomarkers are needed to investigate the impact of smoking withdrawal on
brain function. NFL-101 is a denicotinized aqueous extract of tobacco leaves currently …

Caspase 9b drives cellular transformation, lung inflammation, and lung tumorigenesis

M Kim, NT Vu, X Wang, GB Bulut, MH Wang… - Molecular Cancer …, 2022 - AACR
Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic
Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that …

NADH Intraperitoneal Injection Prevents Lung Inflammation in a BALB/C Mice Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

N Slama, A Abdellatif, K Bahria, S Gasmi, M Khames… - Cells, 2024 - mdpi.com
Cigarette smoke is one of the main factors in Chronic Obstructive Pulmonary Disease
(COPD), a respiratory syndrome marked by persistent respiratory symptoms and increasing …