Immunomodulatory imide drugs (IMiDs) including thalidomide, lenalidomide, and
pomalidomide, can be used to induce degradation of a protein of interest that is fused to a …

The snow crab (Chionoecetes opilio) fishery off the east coast of Newfoundland and
Labrador, Canada, has been impacted by annual seismic oil and gas surveying in recent …

Targeted protein degradation (TPD) encompasses a growing number of chemical biology
strategies to induce degradation of specific biomolecules, enabling pharmacological …

Growing malignant tumors must evade destruction by the immune system, a hurdle some
malignancies overcome by attracting immune-suppressive regulatory T-cells (Tregs) 1. The …

Helios was related to the immunosuppressive capacity and stability of regulatory T cells.
However, the significance of Helios in follicular help T (TFH) and follicular regulatory T (TFR) …

The IKAROS family of transcription factors comprises four zinc-finger proteins (IKAROS,
HELIOS, AIOLOS, and EOS), which over the last decades have been established to be …

Targeted protein degradation and induced proximity refer to strategies that leverage the
recruitment of proteins to facilitate their modification, regulation or degradation. As …

The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and
lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular …

Small molecules promoting protein-protein interactions produce a range of therapeutic
outcomes. Molecular glue degraders exemplify this concept due to their compact drug-like …

The majority of clinical degrader candidates utilize an immunomodulatory imide drug (IMiD)-
based derivative, that directs their target substrate to the E3 ligase receptor Cereblon …