The amino acid antiporter system Xc− is important for the synthesis of glutathione (GSH) that
functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent …

The main chemical component of cannabis, cannabidiol (CBD), has been shown to have
antitumor properties. The present study examined the in vitro effects of CBD on human …

Abstract Objective Withaferin A (WA) is a bioactive compound with a remarkable anti‐cancer
effect derived from Withania somnifera, commonly known as ashwagandha. However, the …

Significant evidences indicate that reactive oxygen species (ROS) can induce
macroautophagy/autophagy under both physiological and pathological conditions. Although …

The autophagic clearance of mitochondria has been defined as mitophagy, which is
triggered by mitochondrial damage and serves as a major pathway for mitochondrial …

Emerging evidence has shown that cinobufagin, as an active ingredient of Venenum
Bufonis, inhibits tumor development. The aim of this study was to investigate the inhibitory …

Multidrug resistance (MDR) is a serious obstacle encountered in cancer treatment, in which
the overexpression of P-glycoprotein (P-gp) plays an important role. Here, a novel α …

Gliomas are the most common primary intracranial neoplasms among all brain
malignancies, and the microtubule affinity regulating kinases (MARKs) have become …

Background Dose-dependent irreversible cardiac toxicity of doxorubicin (DOX) becomes a
major obstacle for the clinical use. Nowadays much attention is being paid to combination …

Nonsubstrate allosteric inhibitors of P-glycoprotein (Pgp), which are considered promising
modulators for overcoming multidrug resistance (MDR), are relatively unknown. Herein, we …