Molecular imaging in drug development
JK Willmann, N Van Bruggen, LM Dinkelborg… - Nature reviews Drug …, 2008 - nature.com
Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …
processes in living subjects. Such technologies therefore have the potential to enhance our …
Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives
Nanoparticle-based contrast agents are quickly becoming valuable and potentially
transformative tools for enhancing medical diagnostics for a wide range of in-vivo imaging …
transformative tools for enhancing medical diagnostics for a wide range of in-vivo imaging …
Fluorescent nanodiamonds: past, present, and future
Multi-color fluorescent nanodiamonds (FNDs) containing a variety of color centers are
promising fluorescent markers for biomedical applications. Compared to colloidal quantum …
promising fluorescent markers for biomedical applications. Compared to colloidal quantum …
PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)–conjugated radiolabeled iron oxide nanoparticles
The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for
PET and MRI scans of tumor integrin αvβ3 expression. Methods: Polyaspartic acid (PASP) …
PET and MRI scans of tumor integrin αvβ3 expression. Methods: Polyaspartic acid (PASP) …
Nanovehicular intracellular delivery systems
A Prokop, JM Davidson - Journal of pharmaceutical sciences, 2008 - Elsevier
This article provides an overview of principles and barriers relevant to intracellular drug and
gene transport, accumulation and retention (collectively called as drug delivery) by means of …
gene transport, accumulation and retention (collectively called as drug delivery) by means of …
Nanotechnology in medical imaging: probe design and applications
DP Cormode, T Skajaa, ZA Fayad… - … , and vascular biology, 2009 - Am Heart Assoc
Nanoparticles have become more and more prevalent in reports of novel contrast agents,
especially for molecular imaging, the detection of cellular processes. The advantages of …
especially for molecular imaging, the detection of cellular processes. The advantages of …
Emerging concepts in molecular MRI
DE Sosnovik, R Weissleder - Current opinion in biotechnology, 2007 - Elsevier
Molecular magnetic resonance imaging (MRI) offers the potential to image some events at
the cellular and subcellular level and many significant advances have recently been …
the cellular and subcellular level and many significant advances have recently been …
Cell tracking with optical imaging
EJ Sutton, TD Henning, BJ Pichler, C Bremer… - European …, 2008 - Springer
Adaptability, sensitivity, resolution and non-invasiveness are the attributes that have
contributed to the longstanding use of light as an investigational tool and form the basis of …
contributed to the longstanding use of light as an investigational tool and form the basis of …
Magnetic and fluorescent nanoparticles for multimodality imaging
The development of nanoparticulate contrast agents is providing an increasing contribution
to the field of diagnostic and molecular imaging. Such agents provide several advantages …
to the field of diagnostic and molecular imaging. Such agents provide several advantages …
Molecular magnetic resonance imaging in cardiovascular medicine
DE Sosnovik, M Nahrendorf, R Weissleder - Circulation, 2007 - Am Heart Assoc
magnetofluorescent nanoparticle. 19, 20 In addition, many copies of the targeting ligand can
subsequently be attached to the CLIO-fluorochrome conjugate to form a multivalent (1 …
subsequently be attached to the CLIO-fluorochrome conjugate to form a multivalent (1 …