Molecular imaging in drug development

JK Willmann, N Van Bruggen, LM Dinkelborg… - Nature reviews Drug …, 2008 - nature.com
Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …

Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives

MA Hahn, AK Singh, P Sharma, SC Brown… - Analytical and …, 2011 - Springer
Nanoparticle-based contrast agents are quickly becoming valuable and potentially
transformative tools for enhancing medical diagnostics for a wide range of in-vivo imaging …

Fluorescent nanodiamonds: past, present, and future

MH Alkahtani, F Alghannam, L Jiang, A Almethen… - …, 2018 - degruyter.com
Multi-color fluorescent nanodiamonds (FNDs) containing a variety of color centers are
promising fluorescent markers for biomedical applications. Compared to colloidal quantum …

PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)–conjugated radiolabeled iron oxide nanoparticles

HY Lee, Z Li, K Chen, AR Hsu, C Xu, J Xie… - Journal of Nuclear …, 2008 - Soc Nuclear Med
The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for
PET and MRI scans of tumor integrin αvβ3 expression. Methods: Polyaspartic acid (PASP) …

Nanovehicular intracellular delivery systems

A Prokop, JM Davidson - Journal of pharmaceutical sciences, 2008 - Elsevier
This article provides an overview of principles and barriers relevant to intracellular drug and
gene transport, accumulation and retention (collectively called as drug delivery) by means of …

Nanotechnology in medical imaging: probe design and applications

DP Cormode, T Skajaa, ZA Fayad… - … , and vascular biology, 2009 - Am Heart Assoc
Nanoparticles have become more and more prevalent in reports of novel contrast agents,
especially for molecular imaging, the detection of cellular processes. The advantages of …

Emerging concepts in molecular MRI

DE Sosnovik, R Weissleder - Current opinion in biotechnology, 2007 - Elsevier
Molecular magnetic resonance imaging (MRI) offers the potential to image some events at
the cellular and subcellular level and many significant advances have recently been …

Cell tracking with optical imaging

EJ Sutton, TD Henning, BJ Pichler, C Bremer… - European …, 2008 - Springer
Adaptability, sensitivity, resolution and non-invasiveness are the attributes that have
contributed to the longstanding use of light as an investigational tool and form the basis of …

Magnetic and fluorescent nanoparticles for multimodality imaging

WJM Mulder, AW Griffioen, GJ Strijkers… - …, 2007 - Taylor & Francis
The development of nanoparticulate contrast agents is providing an increasing contribution
to the field of diagnostic and molecular imaging. Such agents provide several advantages …

Molecular magnetic resonance imaging in cardiovascular medicine

DE Sosnovik, M Nahrendorf, R Weissleder - Circulation, 2007 - Am Heart Assoc
magnetofluorescent nanoparticle. 19, 20 In addition, many copies of the targeting ligand can
subsequently be attached to the CLIO-fluorochrome conjugate to form a multivalent (1 …