Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities

P Soares, C Silva, D Chavarria, FSG Silva… - Ageing Research …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

Current potential therapeutics of amyotrophic lateral sclerosis

L Lu, Y Deng, R Xu - Frontiers in Neurology, 2024 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a debilitating motor neurological disorder for which
there is still no cure. The disease seriously jeopardizes the health and lifespan of adult …

[HTML][HTML] MyomiRNAs dysregulation in ALS rehabilitation

V Pegoraro, A Merico, C Angelini - Brain sciences, 2019 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder
caused by degeneration of upper and lower motor neurons. The disease process leads …

King's college progression rate at first clinical evaluation: A new measure of disease progression in amyotrophic lateral sclerosis

A Introna, G Milella, A Morea, M Ucci… - Journal of the …, 2021 - Elsevier
Abstract Background To estimate King's college clinical stage progression rate (ΔKC) at first
clinical evaluation in order to define its predictive and prognostic role on survival in a large …

[PDF][PDF] ALS: tautimekanismi ja perinnöllisyys

S Viiliäinen - 2023 - oulurepo.oulu.fi
Tässä kirjallisuustutkielmassa tutkitaan ALS: a, eli amyotrofista lateraaliskleroosia. ALS on
motoneuronisairaus, jossa liikehermot tuhoutuvat vähitellen. Tästä johtuen lihakset eivät saa …

[PDF][PDF] Application of Advanced Multimodal Brain Imaging Techniques to Amyotrophic Lateral Sclerosis

RJ Broad - 2019 - research.brighton.ac.uk
Application of advanced multimodal brain imaging techniques to amyotrophic lateral sclerosis.
Page 1 Application of advanced multimodal brain imaging techniques to amyotrophic lateral …

Myomirnas Role in Als Suggest a Crosstalk between Muscle and Motor Neuron

V Pegoraro, A Merico, C Angelini - 2018 - preprints.org
Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder
caused by degeneration of upper and lower motor neurons. The disease process leads from …