Epithelial to mesenchymal transition as mechanism of progression of pancreatic cancer: from mice to men

L Greco, F Rubbino, L Laghi - Cancers, 2022 - mdpi.com
Simple Summary The progression of pancreatic cancer (PDAC) involves a series of events
transforming the phenotype of cancer cells, namely epithelial-to-mesenchymal transition …

Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas

J Kuvendjiska, F Müller, P Bronsert, S Timme-Bronsert… - Life, 2023 - mdpi.com
Intraductal papillary mucinous neoplasm (IPMN) is the most common pancreatic cyst and a
precursor of pancreatic cancer (PDAC). Since PDAC has a devastatingly high mortality rate …

[HTML][HTML] Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma

E Llop, PE Guerrero, A Duran, S Barrabés… - World Journal of …, 2018 - ncbi.nlm.nih.gov
Pancreatic cancer (PaC) shows a clear tendency to increase in the next years and therefore
represents an important health and social challenge. Currently, there is an important need to …

Next-generation sequencing in pancreatic cancer

GQ Shen, EM Aleassa, RM Walsh, G Morris-Stiff - Pancreas, 2019 - journals.lww.com
Pancreatic ductal adenocarcinoma (PDAC) is lethal, and the majority of patients present with
locally advanced or metastatic disease that is not amenable to cure. Thus, with surgical …

[HTML][HTML] Pancreatic cancer: disease dynamics, tumor biology and the role of the microenvironment

D Ansari, H Friess, M Bauden, J Samnegård… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Pancreatic cancer is known for its propensity to metastasize. Recent studies have
challenged the commonly held belief that pancreatic cancer is a stepwise process, where …

[HTML][HTML] Development and clinical validation of discriminatory multitarget digital droplet PCR assays for the detection of hot spot KRAS and NRAS mutations in cell-free …

S Hussung, M Follo, RFU Klar, S Michalczyk… - The Journal of Molecular …, 2020 - Elsevier
Detection and quantification of tumor-derived KRAS and NRAS mutations in plasma cell-free
DNA (cfDNA) holds great potential for cancer diagnostics and treatment response …

Measurement of portal vein blood circulating tumor cells is safe and may correlate with outcomes in resected pancreatic ductal adenocarcinoma

MG White, A Lee, D Vicente, C Hall, MP Kim… - Annals of surgical …, 2021 - Springer
Background This study investigated the safety and feasibility of intraoperative portal vein
blood (PVB) collection at the time of pancreatic ductal adenocarcinoma (PDAC) resection …

Pancreatic cancer circulating tumor cells: applications for personalized oncology

BJ DiPardo, P Winograd, CM Court… - Expert review of …, 2018 - Taylor & Francis
Introduction: Pancreatic cancer (PC) is a highly lethal disease, in part because of early
metastasis, late diagnosis, and limited treatment options. Circulating tumor cells (CTCs) are …

Multiplex Digital Polymerase Chain Reaction on a Droplet Array SlipChip for Analysis of KRAS Mutations in Pancreatic Cancer

Q Hu, F Kanwal, W Lyu, J Zhang, X Liu, K Qin… - ACS …, 2022 - ACS Publications
Pancreatic cancer is a terminal disease with high mortality and very poor prognosis. A
sensitive and quantitative analysis of KRAS mutations in pancreatic cancer provides a tool …

Circulating tumour cells in pancreatic cancer: A systematic review and meta-analysis of clinicopathological implications

TCY Pang, JW Po, TM Becker, D Goldstein, RC Pirola… - Pancreatology, 2021 - Elsevier
Background The detection and quantification of circulating tumour cells (CTCs) in pancreatic
cancer (PC) has the potential to provide prognostic information. The aim of this review was …