Circulating tumor cells (CTCs), a population of cancer cells that represent the seeds of
metastatic nodules, are a promising model system for studying metastasis. However, the …

Metastatic disease is the leading cause of pancreatic ductal adenocarcinoma (PDAC)
associated death. PDAC cells invade and enter the bloodstream early, before frank …

Pancreatic cancer is the fourth leading cause of cancer-related mortality. Its early diagnosis
is difficult; therefore, no improvement has been seen in its survival rate in recent years …

Les mutations somatiques présentes dans les gènes RAS (KRAS et NRAS) sont largement
associées à l'absence de réponse aux traitements par immunothérapie ciblant le récepteur …

Cancer is the second highest cause of death globally. In an estimated 90% of all cases, the
spread of cancer cells from the initial tumor to a distant site—aka metastasis—is the primary …

Liquid biopsies are becoming increasingly important as a potential replacement for existing
biopsy procedures which can be invasive, painful and compromised by tumour …

Liquid Biopsy ermöglicht die Diagnosestellung einer Tumorerkrankung durch die
Untersuchung von Körperflüssigkeiten. Hierfür sind verschiede Verfahren möglich. Die …

ABSTRACT Background Circulating tumour cells (CTCs) have emerged as liquid biopsy
biomarker providing non-invasive assessment of cancer progression and biology. We …

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
malignancies worldwide. More than 50% of patients are diagnosed with late-stage disease …

Pancreatic cancer is a disease with dismal prognosis due to late detection and ineffective
treatments. The majority of the patients already have disseminated disease at the time of …